If a piece of DNA has the sequence: ATGCCG, which of the following would indicate a base substitution mutation?
ATGCCG |
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ATGGCG |
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TACGGC |
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ATGAACCG |
Answer: Option 2 (ATGGCG) is correct because in this only one nucleotide is changed during DNA replication.
Base Substitution is a gene-level mutation in which one nucleotide is substituted with another nucleotide during DNA Replication. In this, only a single nucleotide is affected in gene sequence so as a result only one codon is affected.
If a piece of DNA has the sequence: ATGCCG, which of the following would indicate a...
A single mutation has occurred in the following DNA sequence. 5' ATG TTC CAG CCA 3' wild-type (normal) sequence 5' ATG TTC TAG CCA 3' mutant sequence a) Identify and classify the mutation according to its molecular structure (i.e., insertion, deletion base substitution (transversion), or base substitution (transition)). Briefly explain why you selected this classification. b) Identify and classify the mutation according to its functional effects (i.e., frameshift, missense, nonsense, or silent). Briefly explain why you selected this classification.
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