Question

8. (1pt) In humans, the DMD gene is required for proper muscle function. Mutations in the DMD gene display X-linked recessive inheritance that leads to muscular dystrophy. The DMD gene has enhancers that are required for gene expression in specific muscles of the body. enh1 is required for expression in the heart: enh2 is required for expression in the arm muscles, enh3 is required for expression in the leg muscles. For an individual with the genotype listed below, what phenotype would you expect?[+= wildtype/full function. E non functional, assume wildtype promoter sequences) enh1- enh2+ enh3- DMD+ enh1- enh2+ enh3+ DMD+ muscular dystrophy in the heart, arm, and leg muscles no muscular dystrophy in any areas muscular dystrophy in the heart and arm muscles, no muscular dystrophy in the leg muscles muscular dystrophy in the leg and arm muscles, no muscular dystrophy in the heart muscular dystrophy in the heart and leg muscles, no muscular dystrophy in the arm muscles muscular dystrophy in the heart, no muscular dystrophy in the arm muscles, mosaic or variable for muscular dystrophy in the leg muscles no muscular dystrophy in the arm muscles, mosaic or variable for muscular dystrophy in the leg muscles and heart

Answer 1

The 6th option is answer that is muscular dystrophy in the heart, no muscular dystrophy in arm muscles, mosaic or variable for muscular dystrophy in the leg muscles.

# As the inheritance is X-linked recessine to for experession of muscular dystrophy in any given muscle. Enkt enhl- enhl- enhat enhat enh 3 -- DMOT enhat Dmot en het $ Showes muscular dystrophy in hearita Homozgons enthat) 4 No muscular dystrophy in armis temorygcus for a en 13 - 9 st Variable or mosaicfamuscular dystrophy in leg enhat) muscles ( Heterozygous for enh 3)