Question

Proшрс: The Central Nervous System is considered "immunologically privileged." What does this mean? What are the features of the anatomical structures that that enable this status. What are the factors that can cause a breach into the status of this system? How do these characteristics play a role in the efficacy of treating infections in the Nervous System, and can they contribute to the occurrence of latent infections within this system?

Answer 1

Ans- CNS an isolation from the immune system by the blood–brain barrier (BBB), the lack of draining lymphatics...A highly selective blood brain barrier regulate the exchange of between the blood and brain

Blood brain barrier are permeable to water carbon dioxide oxygen and most lipid soluble substance such as alcohol and almost totally impermeable to plasma protein and most non lipid soluble large organic molecule

Substance such as glucose amino acid ,and ions exchanged between the blood and brain interstitial fluid are transported by highly selective membrane bound carriers .Thus transport across brain capillary walls between the wall forming cells is anatomically prevented and transport through the cells is physiologically restricted

The CSF OR CEREBROSPINAL FLUID is a colourless liquid that acts as a shock absorbing fluid.The CSF formed in the choroids plexuses of each lateral ventricle flows into the third ventricle through two narrow opening,the interventricular foramina.The fourth ventricle is located Superior to the pons and the medulla oblongata

CSF circulates in the central canal of the spinal cord and in the subarachnoid space around the surface of the brain and spinal cord

MICROGLIA acts the immune defence cells of the CNS and phagocytose foreign and degenerated materials

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