Question

question: What happened to Jesse Gelsinger? How could it have been avoided? What role does greed play in these cases?

this is a case for biomedical ethics.

Can you please make sure the answer to be at least 12 sentence thank you!!!

Answer 1

17-year-old jesse Gelsinger suffered from a genetic disease called ornithine transcarbamylase (OTC) Deficiency .

OTC dfeiciency is a genetic disease that prevents the body from beaking down ammonia, which is a metabolic waste product .In OTC patients the excessive build up of ammonia often causes Death soon after birth ,unless the patients diet is immediately adjusted and monitored throughout their entire life .Jesse lived on a strict non -protein diet and he controlled his OTC fairly well .Jesse volunteered for a gene therapy experiment designed to test possible treatments for OTC . He thought he could help newborns afflicted with OTC by being a volunteer in the experiment .He enrolled as a subject in a gene therapy experiment in which a vector carrying a normal OTC gene was injected into his liver .The vector being used to deliver the OTC gene was called adenovirus -which is a modified version of the virus that  causes you to get a cold.For the most part .jesse was informed subjects had received adenovirus without serious complications .But for some reason jesse was different .After injection of the vector ,a fatal reaction was triggered .Four days after the injection ,Jesse Gelsinger died .

There are number of ethical issues that have emerged from Gene therapy research and particularly from the gelsinger case .