Question

Assigned Gene: SGTA

1. Give a summary of your topic?

2. List all references for the gene or disease?

3. How many Ref Sequences?

4. In the Protein Human Atlas, What tissue is it expressed in? Where in the cell is it located in?

5. How many Clinical Test were preformed and list some?

Answer 1

Role and functions of SGTA gene coding Small glutamine-rich tetratricopeptide repeat-containing protein alpha.

References for the gene or disease.

1. Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans. (PMID: 9740675) Kordes E et al. Genomics 1998.

2. Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome. (PMID: 18332089) Goodarzi MO et al. Human reproduction (Oxford, England) 2008.

3. Structural and functional characterization of human SGT and its interaction with Vpu of the human immunodeficiency virus type 1. (PMID: 18759457) Dutta et al. Biochemistry 2008.

4. SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis. (PMID: 16580629) Yin H et al. Biochemical and biophysical research communications 2006.

5. Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions. (PMID: 15708368) Liou ST et al. Archives of biochemistry and biophysics 2005.

6. The roles of cytosolic quality control proteins, SGTA and the BAG6 complex, in disease. (PMID: 30635083) Benarroch. R et al. Adv Protein Chem Struct Biol. 2019.

7. MicroRNA-138 regulates cell adhesion-mediated drug resistance phenotype by targeting SGTA in non-Hodgkin's lymphoma. (PMID: 30180469) Wu YX et al. Zhonghua Xue Ye Xue Za Zhi. 2018.

8. Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha. (PMID: 26734616) Roberts JD et al Front Mol Biosci. 2015.

9. Expression and prognostic role of SGTA in human breast carcinoma correlates with tumor cell proliferation. (PMID: 25027991) Zhu T et al. J Mol Histol. 2014.

10. Expression of small glutamine-rich TPR-containing protein A (SGTA) in Non-Hodgkin's Lymphomas promotes tumor proliferation and reverses cell adhesion-mediated drug resistance (CAM-DR). (PMID: 24974147) Wang Y et al. Leuk Res. 2014.

Ref Sequences:

There are more than 100 reference sequences:

Sequence Source	Accession No	Protein Accession No
genomic	AC006538.1	AAD13117.1
genomic	CH471139.2	EAW69366.1
mRNA	AF368279.1	AAP29457.1
mRNA	AF408399.1	AAL01051.1
mRNA	AJ133129.1	CAB39725.1
mRNA	AJ223828.1	CAA11565.1
mRNA	AK293535.1	BAG57017.1
mRNA	AL050156.1	CAB43297.2
mRNA	BC000390.2	AAH00390.1
mRNA	BC002989.1	AAH02989.2
mRNA	BC005165.2	AAH05165.1
mRNA	BC008885.2	AAH08885.1
mRNA	CR533517.1	CAG38548.1
mRNA	CR542282.1	CAG47077.1

As per Protein Human Atlas, the SGTA is located in the below cell compartments.

Compartment	Confidence
nucleus	5
cytosol	5
plasma membrane	2
extracellular	2
mitochondrion	2
endoplasmic reticulum	2
cytoskeleton	1
peroxisome	1
endosome	1
lysosome	1
golgi apparatus	1

Clinical Test:

SGTA Single Gene

This is a clinical test intended for: Diagnosis, Mutation Confirmation

Deletion/duplication analysis: Next-Generation (NGS)/ massively parallel sequencing (MPS)

Sequence analysis of the entire coding region: Next-Generation (NGS)/ massively parallel sequencing (MPS)

Fulgent Genetics, FLGT

Fulgent Genetics

Clinical Diagnostics Lab

4978 Santa Anita Ave.

Suite 205

Temple City, California 91780

United States