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describe a decarboxylation-redox reaction that occurs during glucose metabolism

describe a decarboxylation-redox reaction that occurs during glucose metabolism
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Decarboxylation-redox reaction occurring in glucose metabolism = The conversion of pyruvate to Acetyl CoA
The conversion of pyruvate to Acetyl CoA is an example of an oxidative decarboxylation reaction. In this reaction, Pyruvate (3C) is converted to Acetyl CoA (2C). One CO2 molecule is released = Decarboxylation.
In this reaction, 1 NAD+ is reduced to NADH = Redox reaction.

This reaction is catalyzed by Pyruvate dehydrogenase complex. It is also known as the link/transition reaction. It occurs in the mitochondrial matrix in eukaryotes and cytoplasm in prokaryotes.

Pyruvate + CoASH + NAD+ ----------> Acetyl CoA + CO2 + NADH + H+

The pyruvate dehydrogenase complex requires five cofactors.
1. NAD+
2. FAD
3. Lipoic acid
4. Coenzyme A
5. TPP

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