Question

Can someone confirm that this is correct. Thanks!

15–26. The proteins involved in vesicle transport must return to their starting place or be degraded. Otherwise you would fill the target membrane with the protein. Match each of the proteins on the left to its appropriate way of return listed on the right. Proteins methods of return A. no need to recycle B. released into cytoplasm C. recycled by vesicles - 15. Cargo receptors in the ER C. recycled by vesicles 16. Sari B. released into cytoplasm 17. Rabs on vesicles B. released into cytoplasm 18. Rabs on target membrane A. no need to recycle - 19. Rab GEFs B. released into cytoplasm 20. Rab GAPS B. released into cytoplasm 21. CopII B. released into cytoplasm 22. Copi B. released into cytoplasm 23. V-snares C. recycled by vesicles 24. T-snare A. no need to recycle 25. Scaffold proteins C. recycled by vesicles - 26. Snap25 A. no need to recycle =

Answer 1

Solution:

Options 15, 16, 17 and 18 are true. Cargo receptors in the ER are are generally recycled back through retrograde transpot mechanism. Sar 1 and Rab are GTP binding proteins whic act as key regulators in vesicle trafficking. Both Sar 1 and Rab proteins on the mebranes are recycle in to the cytoplasm in GDP bounded form. Rabs on target membrane called as rab effectors are not at all recycled.