Question

please answer both the question .

7. Explain the underlying molecular and immunological basis of coeliac disease. 8. marks] Outline a dietary strategy for treating coeliac disease. What would you advise coeliac patients with regard to consumption of wheat or rice? [5 marks]

Answer 1

Pulude ( Corliae disease is an immune -mediated dironder resulting in nutrient malabsouption now thought to have a pnevalence of between 1.100 and trand in the UK' population . Symptoms can frannhora, steatonnhora, weight was, weakness and fagitiue. In addition to the morbidity associated with presenting symptoms, patient bone disease, entenopathy alwoled pa cell lymphoma and other malignanele. There appears to be a strong genetic component to this disease. This anticle provides a short review of the histonical clinical and genetic aspects of this disease and highlights sevenal findings from neuent structural and molecular Immunology studies. A model of the pathogenesie is proposed where the contributions of innate and adaptive immune eystems are delineated and the sential dual roles of gradin in the initration and maintenance of the disease and summarind, finally, portential fut une therapeletic options based on this new undeneting are discussed, I The keystone of cD pathogenesis is an adaptore immune nesponse on chestrated by the interplay between gluten and mic clas molecules Yet, other factors that impair immunoregulatory

Pulude ( Corliae disease is an immune -mediated dironder resulting in nutrient malabsouption now thought to have a pnevalence of between 1.100 and trand in the UK' population . Symptoms can frannhora, steatonnhora, weight was, weakness and fagitiue. In addition to the morbidity associated with presenting symptoms, patient bone disease, entenopathy alwoled pa cell lymphoma and other malignanele. There appears to be a strong genetic component to this disease. This anticle provides a short review of the histonical clinical and genetic aspects of this disease and highlights sevenal findings from neuent structural and molecular Immunology studies. A model of the pathogenesie is proposed where the contributions of innate and adaptive immune eystems are delineated and the sential dual roles of gradin in the initration and maintenance of the disease and summarind, finally, portential fut une therapeletic options based on this new undeneting are discussed, I The keystone of cD pathogenesis is an adaptore immune nesponse on chestrated by the interplay between gluten and mic clas molecules Yet, other factors that impair immunoregulatory