Question

Rabies is a single-stranded RNA virus that is a negative sense virus. Draw how a 6-nucleotide sequence of its genome would look (random sequence with all nucleotides represented). Please have the appropriate number of strands, different types of bonds and different components to the nucleotide in the drawing

Answer 1

Let us take the random 6 nucleotide RNA sequence as AUGUCG. Since it is a single stranded RNA, so no hydrogen bonds will be present. Phosphodiester Bond will be present between two ribose sugars. The labelled diagram will look as

This image is drawn digitally, so that it is more understandable and clear to you. Everything is represented properly in this diagram.

5' End 3' End Direction Phosphate O -O-P-04 I O= -O- -O-P- 0.1 P O но, Ribose Sugar HO YN N IN HEN HN | H ) HN 1 HNN || ) N H2N HN ] O HANN Adenine Uracil Guanine Uracil Cytosine Guanine

Moreover, Negative Sense Single stranded RNA means that the strand actually runs from 3' end to 5' end. That's the reason why i have drawn it in 3' ------> 5' direction. In order to express its genome, this negative strand is firstly converted into its complementary positive strand and then it is further translated into the proteins. That's how these viruses work.

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