Question

References Mallings Review View AaBbcode Acade Aa A ELEVEREE ! PAESE Evvv No Spacing becurs, APC activates two proteins, the enzyme seperase and cyclin B. APC also deactivates the cyclin-dependent kinase Cdk1. Seperase cleaves the proteins holding sister chromatids together, called _cohesion complex allowing them to separate. Cdki is dephosphorylated by a protein phosphotase an enzyme that removes a phosphate, and so the cell can exit mitosis. When it does, it will be in the phase, a part of the majority of the cell cycle known as a. What would happen if there was a mutation that caused APC to always be phosphorylated? (2 points). b. When cell cycle checkpoints do not properly regulate cell division, this type of disease is broadly called cancer

Answer 1

Answer: APC activates two proteins, the enzyme separase and cyclin B. APC also deactivates the cyclin-dependent kinase Cdk1. Separase cleaves the proteins holding sister chromatids together, called SMC1, SMC3 cohesion complex Scc1, allowing them to separate. Cdk1 is dephosphorylated by a Ptp1 protein phosphatase, the kinase is an enzyme that removes a phosphate, and so the cell can exit mitosis. When it does, it will be in the G1 phase, a part of the majority of the cell cycle known as Interphase.

(a) if there was a mutation that caused APC to always be phosphorylated then it attaching a phosphate group to its targets, it adds a small protein tag called ubiquitin (Ub). When a target is tagged with ubiquitin, it is sent to the proteasome, which can be thought of as the recycle bin of the cell, and destroyed. And this process will be happening continuously causing DNA damage of self cells.

(b) When cell cycle checkpoints do not properly regulate cell division, this type of disease is broadly called cancer.