Describe how the H4 and M4 isozymes of LDH are differentially suited for their purposes.
Describe how the H4 and M4 isozymes of LDH are differentially suited for their purposes.
Homework Answers
Answer :- H4 isozymes predominently found in heart whereas M4 in skeletal muscle. H4 isozymes of LDH involved in aerobic oxidation of pyruvate where as M4 isozymes are involved in anaerobic metabolism and pyruvate reduction in liver and skeletal muscle. H4 is active at low concentration of pyruvate thus it presents in tissue with low concentration of pyruvate, which is heart tissues. M4 on otherhand higher activity at high concentration of pyruvate which favour anaerobic metabolism hence found in tissues like skeletal muscles.
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Describe how the H4 and M4 isozymes of LDH are differentially
suited for their purposes.
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