a )The common methods used to drug delivery in camcer using nanoparticles technology are
1.Protein bound nano drug. the nanoparticles drugs are enclosed in protein , so that it ensures the release of drugs at needed place. eg Paclitmel drug used in breast cancer treatment
2.liposomes bound nano particle drug. the drugs are enclosed in liposomes
eg Doxil used in treatment of kaposi sarcoma
b) The regulatory mechanisms steps are following
1.The hormones are the cellular mediators help in stimulation and controling growth response extracellularly,
2. when a hormone binds to its receptor, this stimulates the enzyme activation in cell, leads to growth or suppression according to hormones bind to the receptors
6. Nocowadisioe drug delivery in cancer a. What method is used to delivery drug during cancer...
The biotechnology drug cetuximab (ER-BITUX), used in the treatment of colorectal cancer, has a loading dose of 400 mg/m2administered as an intravenous infusion over a 120-minute period. Using an IV set that delivers 15 drops/mL, calculate (a) the dose (in mg) for a patient with a BSA of 1.6 m2, and (b) the rate of delivery, in drops/min, for 250 mL of an IV fluid containing the dose.
Tamoxifen is a drug used in the treatment of certain types of breast cancer. It works by blocking intracellular estrogen receptors. A structural formula for Tamoxifen can be drawn on the following way: N(CH3)2 8. On the structural formula, highlight the functional groups and name them.
Tamoxifen is a drug used in the treatment of certain types of breast cancer. It works by blocking intracellular estrogen receptors. A structural formula for Tamoxifen can be drawn on the following way: N(CH3)2...
You are trying to design a drug that can be used to treat cancer and you decide that your drug will target the cell cycle. Explain how your drug would work (1 sentence) and why this would be useful in treating cancerous cells (1 sentence)
In a trial of a cytotoxic drug for lung cancer treatment, the investigators reported 6 deaths among 60 patients treated with this agent, compared with 15 deaths among 58 controls on placebo. Calculate the attributable benefit of this agent in reducing lung cancer-related mortality in this population.
Cancer and Gene Regulation Why is a cell cycle control system needed for cell division? What happens when cells do NOT respond to the cell cycle control system and divide excessively? Tumor Proto-oncogeno (for protein that stimulates coll division) 6 Y DNA Benign Tumor= Mutation withln a control region of DNA Malignant Tumor Mutated promoter Metastasis Normal growth-stimulating protein in excess Oncogene Tumor-Suppressor Genes Proto-oncogene utled tara gese Samor-auppresr gane Many proto-oncogenes code for growth factors /Deletive nonimenig Normel grewt...
A drug used for treating cancer has potentially dangerous side effects if it is taken in doses higher than needed for treatment. The pharmaceutical company that manufactures the drug must be certain that the standard deviation of the drug content in each tablet is less than 0.1 mg. Fifteen tablets are analyzed to determine the amount of the drug in them. The sample mean is 20 mg, and the sample standard deviation is 0.08 mg. Step 2 of 5: If...
Crizotinib is an anti-cancer drug approved for treatment of non-small cell carcinoma. The synthesis of the drug employs a Suzuki-Miyaura cross-coupling. Which bond was formed via a Suzuki-Miyaura cross-coupling? -NH N-N A B CI Me с NH2 CI D O a. Bond D O b. Bond C O c. Bond B O d. Bond A
A drug, which is used for treating cancer, has potentially dangerous side effects if it is taken in doses which are larger than the required dosage for the treatment. The tablet should contain 56.02mg and the standard deviation should be 0.02. 12 tablets are randomly selected and the amount of drug in each tablet is measured. The sample has a mean of 56.025mg and a variance of 0.0001mg. Does the data suggest at α=0.05 that the tablets vary by less...
A cancer cell undergoes cell division in an unregulated manner (for example, when no growth factors are present). Alterations of the following factors could cause cells to exhibit such ‘uncontrolled growth’ characteristics. Determine whether the gene encoding the specified factor behaves like an oncogene/proto-oncogene or a tumor suppressor gene. Briefly explain your reasoning. A kinase that functions in a growth factor signal transduction pathway. A CDK that functions in cell cycle regulation. A kinase that functions to turn off the CDK described in...