Question

U VIHTCYou auUIT MOMmaion, and Identity donors for deferral. 10 Oist possible adverse donor reactions and the appropriate treatment. 11. Compare and contrast allogeneic and autologous donor criteria. 12. List various forms of autologous donations. 13. Describe the apheresis procedure, the donor requirements, and the products that can be collected 14. Discuss the reason for directed donation and the donor criteria. 15. Define therapeutic phlebotomy and the clinical conditions for its use Blood centers and transfusion services are responsible for providing an adequate and safe blood supply to the patients they serve. Criteria for acceptable blood donors are established by the U.S. Food and Drug Administration (FDA) through the Code of Federal Regulations (CFR), guidance documents, or memoranda to the industry. The A ABB, a voluntary accrediting agency, has established guidelines for blood donation, which are written in the Standards for Blood Banks and Transfusion SermicesIn an effort to provide uniformity and clarity for determining the eligibili

Answer 1

11. ALLOGENIC DONATION-

Allogeneic donation, commonly referred to as whole blood donation, is the process of voluntarily donating a unit of blood (which is around a 470mL) for the national supply.

Blood is in constant demand for treatment of accident cases, cancer victims, people with haemophilia and for use during surgery. The donated blood is separated into components so that one allogeneic donation can help several patients.

If you have an allogeneic transplant, you will get healthy blood-forming cells donated by someone else. The donor can be a family member or someone unrelated to you. Sometimes, people get donated blood-forming cells from umbilical cord blood. This is the blood collected from the umbilical cord and placenta after a baby is born and made available through Be The Match Registry.

The best transplant outcomes (results) happen when a patient’s HLA closely matches the donor’s HLA. A close HLA match also helps lower the risk for problems after transplant. Matching HLA markers is much more complex than matching blood types.

Each brother and sister has a 25% (1 out of 4) chance of completely matching you, if you have the same mom and dad. Your parents and your children always match exactly half of your HLA markers. For some people a transplant from a half-matched donor, or a haploidentical transplant, is a treatment option.

About 70% of patients (7 out of 10) who need a transplant don’t have a close match in their family. If you don’t have a match in your family, your doctor will search the Be The Match Registry for an unrelated donor or umbilical cord blood.

AUTOLOGOUS DONATION-

An autologous blood donation is when a person donates blood for their own use, prior to a scheduled elective surgery. There are actually at least three kinds of autologous procedures: Pre-operative autologous donation - Patient donates his/her own blood prior to surgery.

Blood cannot be collected from a patient within 72 hours of the operation. Informed consent of the patient/donor must be obtained in writing prior to initiating the donation series.

There are no age limits for autologous donors. The minimum weight requirement for autologous donors is 50 kg (110 lbs). Before the first donation, donors must have a minimum hemoglobin of 110 g/l and a minimum hematocrit of 33%. At subsequent donations, the minimum hemoglobin required is 105 g/l with a minimum hematocrit of 32%. The majority of autologous donors donate one or two donations. A maximum of four donations can be collected from the donor/patient. The donations are normally drawn one week apart. Initiation of iron therapy to return the hemoglobin to the pre-donation level is advised, but this is often not done; only 8% of donors were found to be on iron therapy.

• Autologous transfusion means a transfusion in which the donor and the recipient are the same person and in which predeposited blood or blood components are used.

• Autologous donation means blood and blood components collected from an individual and intended solely for subsequent autologous transfusion to that same individual.