Question

genetics help please

6. Anurak is a man who is effected with a disease caused by a mutation in an imprinted gene that is maternally-expressed (paternally silenced). Anurak and his female partner are considering having a child. Imagine you are a genetic counseler. Do you tell them they should worry about their child having the disease or not? Why? (2points) Anurak's mother is considering having a child with her new male partner (not Anurak's father). Imagine you are a genetic counseler. Do you tell them they should worry about their child having the disease or not? Why? (2points) Anurak remembers hearing that one of his parents' grandfathers had the same disease, but he can't remember which parent. Do you think it was his mother's grandmother or his father's grandmother? (1points) Is it surprising that his great-grandfather had the disease, given that she is a female? Why? (2points)

Answer 1

This disease in maternally expressed. It means this disease can be passed only from mother to offspring Maternally an related to mother laternally - related to father Anurak and his female partner should not worry because the mutated gene will be silenced in their offspring because this disease is parternally silenced. Anurak's mother and her new male partner should warry because Anurak's mother have mutated gene which will express itself in their offspring. Hence, their offspring will be diseased. " Suppose if Anurak's father's grandmother had the disease. I This disease was passed to Anurak's father. But these disease cannot be passed to Anurak's because this disease is paternally silenced. But if Anurak's mother' si grandmother had the disease Then this can be passed to A Anurak's mother and passe to Anurak because this disease is maternelly expressed "It means Anurak mother's grandmother had the disease! no, it is not surprising. This disease was able to pass down to Anwarek and his mother because Anurak great grandfather was diseased female. That' why this maternally expressed disease was able to pass down,