How do intermediate filaments connect to other cytoskeletal proteins?
Intermediate filament – associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle (also called a tonofilament) or a network, and with other cell structures, including the plasma membrane. Only a few IFAPs have been identified to date, but many more will undoubtedly be discovered as researchers focus attention on the proteins that control IF organization and assembly. Unlike actin-binding proteins or microtubule-associated proteins, none of the known IFAPs sever or cap intermediate filaments, sequester IF proteins in a soluble pool, or act as a motor protein. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs.
A physical linkage between intermediate filaments and microtubules can be detected with certain drugs. Recall that treatment of cells with high concentrations of colchicine causes the complete dissolution of microtubules after a period of several hours (see Figure 19-6). Although vimentin filaments in colchicine-treated cells remain intact, they clump into disorganized bundles near the nucleus. This finding demonstrates that the organization of vimentin filaments is dependent on intact microtubules and suggests the presence of proteins linking the two types of filaments.
How do intermediate filaments connect to other cytoskeletal proteins?
Intermediate filaments are an essential class of cytoskeletal proteins. Give three examples of how they different from the other cytoskeletal systems, i.e., microtubules and microfilaments. (The best answer will include some details about the other cytoskeletal elements, e.g., composition, proteins that bind actin/tubulin, etc.)
Compare and Contrast all three cytoskeletal elements (microtubules, microfilaments, intermediate filaments).
List, describe, and distinguish the 3 types of cytoskeletal filaments based on: the name of the monomer protein how monomers incorporate into filaments polarity approximate diameter function associated proteins
1) What is nucleation? How are microtubules nucleated? How is Actin commonly nucleated? 2) How do motor proteins work? Why is it important that these proteins have two domains that interact with the cytoskeletal element (“feet”)? 3) Give two examples of Actin binding proteins that would affect actin dynamics. 4) Intermediate filaments are very different from the other two cytoskeletal elements. What are those differences?
Question 44 (1 point) When two cells are joined by proteins that bind to each other, and to the proteins that anchor cytoskeletal intermediate filaments, are formed. o tight junctions desmosomes plasmodesmata gap junctions
Which of the following associate with kinesin and dynein? O Microtubules O Microfilaments Intermediate filaments All of the above Two of the above None of the above All movement of organelles along cytoskeletal proteins uses ATP as the energy source. True False
What are the advantages of having cytoskeletal filaments constructed using polymers? what are the advantages of having cytoskeletal filaments constructed through protofilaments? Thanks in advance !!
12. Individual cytoskeletal filaments are typically organized into more complex structures within the cytosol. What two general types of structures do individual filaments combine to form in the cytosol? How are these structures created and maintained?
What are the advantages of having cytoskeletal filaments constructed through protofilaments?
For each of the following, decide whether it applies to actin filaments, intermediate filaments, and/or microtubules. NOTE: there may be multiple answers for each statement. Found in the nucleus and cytoplasm ANSWER: Involved in the transport of vesicles and organelles ANSWER: Associate with proteins that help adhere cells to the extracellular matrix ANSWER: Their stability is influenced by nucleotide hydrolysis ANSWER: Directly involved in phagocytosis ANSWER: Can associate into bundles with the help of other proteins ANSWER: