5. Mutations can occur in both
coding and noncoding regions of a gene.
Mutations that occur in the coding region are qualitative i.e. they
affect (increase/decrease) the activity of the gene product.
Mutations that occur in the noncoding region are quantitative i.e.
they affect the amount of the gene product produced.
These noncoding regions include a promoter, silencer, operator, and
enhancer.
1. Mutations in the promoter region
result in the inability of RNA polymerase to bind to the target
gene locus resulting in transcriptional repression.
2. Mutations in the silencer region result in the inability of
repressor proteins to bind to it. This leads to the enhanced
recruitment of RNA polymerase to the target gene locus resulting in
transcriptional activation.
Q5. Closer examination of the two alleles of the human CDC25B gene reveals no changes in...
Why would changes in the genes for transcription factors be expected to generate major phenotypic differences? They are extremely powerful genes. They can affect the expression of small numbers of other genes. Their gene products are remarkably stable. Their gene products normally denature more rapidly than other gene products. They can affect the expression of large numbers of other genes. Which enzyme, also responsible for siRNA formation, carves miRNAs from their double-stranded, fold- back RNA precursor (pre-miRNA)? Dicer ribonuclease RNA...
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