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An increase in intracellular phosphoinositol 3,4,5 triphosphosphate (PIP3): leads to the activation of PI-3 kinase. leads toThe following metabolic effects are accomplished by glucagon signaling: mobilization and fusion with the membrane of GLUT 4 c

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An increase in intracellular phosphoinositol (3,4,5)-trisphosphate (PIP3): leads to glucose absorption via GLUT4 in the muscle and adipose.

The following metabolic effects are accomplished by glucagon signaling: activation of PKA, glycogen breakdown, and gluconeogenesis in the liver.

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