Predict the final product for the following reaction sequence. Diethyl malonate 2-methylheptanoic acid 3-methylhexanoic acid 3-methylpentanoic...
Please show the entire mechanism for this problem, thank you! 46) Malonic ester (diethyl malonate) is treated successively with sodium ethoxide (1 eq.), 1- bromopentane, potassium tert-butoxide, iodomethane, hot aqueous NaOH, HCl, and heat. What is the final product? a) 2-Methylheptanoic acid b) 3-Methylhexanoic acid c) 3-Methylpentanoic acid d) 2-Methylpentanoic acid e) Ethyl 2-methylheptanoate 47) What would be the major product of the following reaction sequence? 1. BH PCC 1. LDA (-78°C) 2. H,02, OH CH,C12 2. CH3CH,Br ఎంత a)...
Malonic ester (diethyl malonate) is treated successively with sodium ethoxide (1 eq.), ethyl bromide, potassium tert-butoxide, isobutyl chloride, hot aqueous NaOH HCI, and heat. What is the final product? 6-Methylheptanoic acid • 2-Ethyl-3-methylpentanoic acid HE Ethylisobutylmalonic acid 4-Ethyl-2-methylpentanoic acid 2 Ethyl-4-methylpentanoic acid
diethyl malonate reacts with propyl bromide in a three step reaction sequence Diethyl malonate reacts with propyl bromide in a three-step reaction sequence. Identify the product that is formed. The highlighted carbons should correspond to the carbons from diethyl malonate. 1. NaOC2H5, C2H5OH 2. NaOH, H2O 3. H30*, heat H₃C way Select the product whose highlighted carbons come from diethyl O = TO O H₃C. WIO xo IO O H,C, с COH Н4С IOSO 0 H₃C, 0 CHCC CHE НАС...
What is the major organic product? i)(CH3)₂ Culi 2) H3O+ Prediet final product i) sodium ethoxide in sodium ethoxide Hot 2) I-bromopentane 2) bromomethane a) 2-methylpentanoic acid cethul z-methylheptanoate b) 2-methul hept anoic acid d) 3-methylhexanoic acid
4. (6 points) What is the condensation product if diethyl malonate is used instead of ethyl acetoacetate? но. но н* heat resorcinol diethyl malonate 1) Is this reaction faster or slower than the reaction with ethyl acetoacetate? 2) Explain why.
Diethyl malonate can be prepared by the following reaction sequence. Draw the structures of each of the missing intermediates in the boxes provided. 4. |сH,сH он. 1. Bry PBr3 OH 2. H2O не На NaCN HSO NC CH CH-OH осH сH, CH2 HQ, heat CH2 HCl OEt Et0 How would you prepare each of the following compounds using either an acetoacetic ester synthesis or a malonic ester synthesis? Show all intermediate structures and all reagents 5. COOH
a Choose the correct IUPAC name for each carboxylic acid. YOH 2,3-dimethylpentanoic acid 3-ethyl-2-methylpentanoic acid 2-methylpentanoic acid 3,4-dimethylpentanoic acid 3-methylpentanoic acid 3-ethylpentanoic acid b VOH NH2 4-aminobutanoic acid aminobutanoic acid 2-aminopentanoic acid 2-aminobutanoic acid 3-aminobutanoic acid 2-aminohexanoic acid COOH pentanoic acid Obutanoic acid valeric acid hexanoic acid propanoic acid caproic acid butyric acid propionic acid
11) Show how to synthesize 2-Methylhexanoic acid using the Malonic Ester Synthesis. Start with Diethyl propanedioate (C7H1204)
8. Give a synthesis of the compound shown starting from either diethyl malonate (DEM) or ethyl acetoacetate (EAA) shown in the box below. Give all reagents necessary. State clearly whether your starting compound is DEM or EAA. You do not need to draw the intermediate steps. 17 pts] Eto Et Hoce DEM ΕΑΑ. 9. Draw the uncharged product of this synthetic sequence. [4 pts] 1. KOH OCH 3. NaOH(aq) excess 10. By how much will the mass of this compound...
10) _ u is the product of the following reaction sequence? Write the structure of A and product B. Mg, Diethyl ether Br A 2. H2O+ A) 3-methyl-3-hexanol C) 2-methyl-3-hexanol B) 2-heptanol D) 3-ethyl-2-pentanol 1) - 11) The reaction of a Grignard reagent with an aldehyde followed by dilute acid gives a n A) tertiary alcohol. B) primary alcohol. C) ester. D) secondary alcohol. 12) What is the product of the following reaction sequence? 12) SOCI 1) CH3CH2CH2MgBr 2) H30*...