Question

The following pedigree shows transmission of galactosemia, a rare autosomal recessive disease caused by the inability to metabolize the sugar galactose, resulting in muscle, nerve, and kidney malfunction. hoch Question 1 5 pts What is the probability that the individual in the 4th generation is affected? O 1/12 O 1/24 O 1/4 O O 1/32 O 1/2 O 1/8 O O
I would like someone to double check my answers please, thank you!

Answer 1

Answer:

• Galactosemia is a autosomal recessive disorder so the possible genotype of this pedigree chart is
• * Note - the external person in pedigree is assumed as homozygous.

gen a h a a recerriue ű an affected Aa - Carrier AA - Normal AA- For External 3rd gen 2/3 a - 0 % person 4th gen As on this pedigree No offspring e the e affected so unaffected person in 1st generation i homozygou. In 3rd generation the probabilty of Mother with Carrier is liã and Father with carrier i 2/3. rather Probability of Alleads Mother IA A 1A child from Carrier parents ě 14. A % . a Aa Aa) a A AA AA a afax As father i not affected affected child in 4th Total probability for generation so, the answer is 1:12.. x - Affected x - Normal Y - Normal 2nd gen. 1 xxxx xx xү and gen. t o y XY In 4th generation in order to affected child the Mother must be carrier and affected child will be male. xx If Male then. probability for affected 4 → 1² X XX XY e probability for gender is - 12 Total probability is Y2X1 X ² Y2 = YB (Ane) Mother Dad gender Male

So the correct answer for question 1 is 1:12

And for question 2 is 1:8

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