2. Ok... so, what is the α-synuclein mutant a mouse model of? (2 points) a) Parkinson’s disease b) Alzheimer’s disease c) ALS
α-synuclein mutant mouse model has been used to understand the therapeutic targets and disease pathogenesis of Parkinson’s disease.
The application of knockout mice has improved the chances to study the expression of genes related to diseases. Since, α-synuclein is the only major protein found related to parkinsons disease, the incorporation of α-synuclein mutant mouse model is vital. α-synuclein mouse model is the most effective because α-synuclein is the only protein part recognized, that has straight effect on Parkinson’s disease progression and pathogenesis.
Parkinson’s disease is considered as the neurodegenerative disorder that affects one per cent of the population having an age over sixty. Identification of parkinsons disease is done by knowing the existence of lewy bodies (which are protein inclusions created by α-synuclein).
Though there exist various other models related to genetic anomalies, none of them are useful in Parkinson’s disease investigation.
2. Ok... so, what is the α-synuclein mutant a mouse model of? (2 points) a) Parkinson’s disease...
1. You are studying an integral plasma membrane protein named LINKER that can interact with the cytoskeletal molecule spectrin to form complex matrices across the surface of membranes. To begin to understand how the LINKER protein population responds to spectrin availability, you perform some fluorescence recovery after photobleaching (FRAP) experiments using a LINKER-GFP fusion protein. The results of a FRAP experiment with the wildtype version of LINKER in which 50% of the protein population is bound to spectrin is shown...