Question

EXERCISE 1 BONE REMODELING Work in a small group or alone to complete this exercise. 1. Describe one hypothetical situation that illustrates the "use it portion of the use it or lose it principle. Description of the situation/behavior: Explanation for why more bone is present under these circumstances: 2. Describe one hypothetical situation that illustrates the "lose it" portion of the use it or lose it principle. Description of the situation/behavior:

Answer 1

Bome remodelling is a dynamic process under the influence of many factors and hormones. Parathyroid hormone leads to bone resorption and calcitonin leads to bone formation.

Answer 1.) Situation where there is more bone formation are :-

A.) In cases of athletes and bodybuilders.

B.) In case of several diseases where there is excessive bone formation.

There is more bone formation in athletes and bodybuilder because due to exercise there is release of several hormones like growth hormone, insulin like growth factors, calcitonin etc. Which plays a crucial role in bome formation, and strain due exercise itself helps bone to grow.

Answer 2.) Situation where bone formation is less are:-

A.) When there is prolonged immobilization of part/limb like in case of comatose patient.

B.) In females after menopause.

There is less bone formation, when there is prolonged immobilization because due to this there is atrophy or disuse wasting of muscles and bones, in bone there is decalcification of bones which leads to decrease in bone density and making them prone to fracture even to a trivial trauma.

In female who are near to there menopause, are prone to decrease bome density and fractures because estrogen is deficient in menopausal women and estrogen has a bone preserving action.