Question

describe actin polymerization and how concentration affects polymerization

Answer 1

Actin is one of the most abundant and highly conserved proteins in eukaryotic cells. The globular protein (G-actin) assembles into long filaments (F-actin), which form a variety of different networks within the cytoskeleton. Actin filaments grow and shrink by attachment and detachment of G-actin monomers at the two filament ends. These processes, which can be studied by Brownian Dynamics simulations are coupled to nucleotide hydrolysis, a two-step process consisting of ATP cleavage and phosphate release. In principle, both processes could be cooperative, i.e., could depend on the local neighborhood of the subunit or protomer in the filament Once the steady-state phase is reached, the equilibrium concentration of the pool of unassembled subunits is called the critical concentration (Cc). This parameter is a measure of the ability of a solution of

G actin polimerize