Question

7. In our synthetic route to barbiturates, the precursor necessary for the preparation of Phenobarbital is A, which is inaccessible via the malonic ester synthesis. Explain why A cannot be synthesized with the malonate synthesis Show the reagents necessary to transform phenylacetonitrile to A. Et 0 8. The following sequence of methylations and Hofmann eliminations was used in the structural determination of the bicyclic amine. Compound B is a mixture of two isomers Ha CH,I CHil Ag,o heat heat

Answer 1

OEL Naos rubluex Na0Et 0 CA) 72 少.Χ. diasid 06,ラ 쉐#x