Question

What biologic platform and design would you use to target E. bola? Justify your answer and describe the mechanism of action of your biologic.

Answer 1

EXPERIMENT Page No. Date: / + /201 Ebola is deadly virus that causes fever, body aches and diarrhea and Sometimes bleeding inside and outside the body. As the virus spreads through the body it damages the immune system and ožgano ultimatalya Pt causes blood cloating cells to doop. This leads to serves uncontrolabie breeding and causes death also cally copooteins Nucleoplasmid polymarase Niral Potcin. genome. Fly: stoucture of Fibera virus] E. bola haring - Genome lg kb long plameter of ebole is g60 nm to loonm. sppkes formed by Gp f /Gp2 complex, mamboane fasole in is affociated with protein enbrope.

No. EXPERIMENT Page No. 2 Date : 1 1201 *l mechanism of Action of Ei bele - o pai munily E. bela enters to human body II by tissue affecting except bones and muscles. - further .E. bola creates blood cloats. Such cloats goes towords to internal organce of the body like Clungs, eyeboll, heart etc). Therefore it prevents oxygen to rpse tissue. Ane.bola.cuso destroys connective tissue Also the f.bela vous po normale trasmitted by dered contact with infected body fluido or skin. whenever Ebola enter's to body it causes viral attack macrophages cind monocytes, relying upon bust antibodies and complement component for efffcrent infection. these ps the general machanism of action found In case of Ebola.

[Ebola vious human bodyt - monocyte Improcrophages Dendritic cell Tissue factor Host Cell Cytokines. Activation of death Receptors. Coagulation Cascada Dysergenceted costimulation Apoptosis Disseminated. coaquicetion). of ympoocytes.