. Show how you would synthesize the following reactions. a. aldol (4 pts.) OH 0 b....
just question B
PROBLEM 1839 Show how to synthesize the following compounds using either an aldol addition or aldol condensation. OH (a) (b)
0.5 pts Question 4 (10 points) Show how you would synthesize the following aromatic compound from benzene and any other reacents necessary. Hint: Retrosynthesis. P .NO2 u h CH3 The reaction code in the box is:
* NH Show how you would synthesize the following compounds from toluene. OH OOH Br NBS
Show how you would synthesize each compound from benzene, toluene, or phenol using the following reactions: Reactions 1. Halogenation 2. Nitration 3. Sulfonation 4. Friedel-Crafts acylation 5. Friedel-Crafts alkylation 6. Oxidation of methyl group 7. Reduction of nitro group • Choose the starting material from the drop-down list • Enter the number(s) of the desired reactions in the order that you wish to use them without commas between • If a reaction is used more than once, enter its number...
3. Show how you would add a Grignard reagent to an acid chloride to synthesize 4-phenylheptan-4-01 4. Show how you would accomplish the following synthesis in good yield. OH benzoic acid N.N-dimethylbenzamide NH HO hexanol heptane-1-amine 0 0 methyl 2-phenylacetate 3-phenylpropionitrile но-л-он
5. Show how you could synthesize the following. (16 pts) A Using the Wittig reaction y vang Ho wang reason Mo + Phypoger 8 ОН Hint: Use the appropriate aldehyde or ketone, and a Grignard Reagent 6. Write the mechanism for the following reaction. (8 points) OH 1. emger 2. H₂O*
How would you synthesize the following reactions? a. H3C CH3 b. Br H3C CH3 Br
skip 5b
4. Show how you would synthesize the following aldehydes by adding the appropriate Grignard reagent to formaldehyde. (a) H (b) H 5. Predict the products of the following reactions: (a) 1.) LIAIH 2.) H,0 (b) CH,CH2CH2CH,CENH CH,CH,M B , then H,0* + 1.) DIBAL-H (-78 C) (c) 2.) H,O OCH3 1) DIBAL-H (-78 C) 2.) H,O 3
5. Give the products for the following aldol reactions.6. Cinnamaldehyde can be synthesized by a mixed aldol condensation reaction. Show the starting materials you would use and write out the reaction mechanism.
Show the two (neutral) organic starting materials that would be used to synthesize the following ketone by a hydroxide mediated crossed-aldol reaction.