Question

5) Resveratrol is a natural compound found in red grapes (and red wine!) and is thought to have beneficial effects in mammals, such as preventing tumor growth and delaying age-related diseases. In vitro, resveratrol and its derivatives have been shown to cause cell-cycle arrest in S phase and induce apoptosis. You have analyzed the DNA content of cultured cells in the presence and absence of these drugs using fluorescence-activated cell sorting. Compared with control cells (dashed line), which of the following curves do you think better represents the DNA content of cells treated with these compounds? (5 Points)

Answer 1

As resveratrol arrests cell cycle in S phase and don't allow the replication of DNA. Hence relative cellular DNA content remain lesser and no cells having replicated (larger amount) DNA will present. Graph D correctly describe the consequences after resveratrol application