Question

23. (5 points total) Resveratrol is a natural chemical compound found in grapes, red wine, and other foods. In a research study, a double-blind, placebo-controlled, randomized trial, 30 women with polycystic ovary syndrome were assigned to take either 1500 mg of resveratrol or a placebo daily for three months. Both before treatment and after three months, blood samples were taken to measure levels of testosterone and other androgen hormones and a glucose tolerance test was performed to determine diabetes risk factors. The result indicated that women who took resveratrol showed a 23.1 percent decline in testosterone levels while those in the placebo group had a 2.9 percent increase. In addition, DHEAS (dehydroepiandrosterone sulfate, a hormone that the body transforms into testosterone) levels declined by 22.2 percent in women who took resveratrol and rose 10.5 percent in women who took placebo These results suggest that resveratrol can be beneficial for women who are living with polycystic ovary syndrome. Although more research is needed, women with PCOS may want to talk to their healthcare provider about taking resveratrol. OH но л ОН A. Circle one of the polar covalent bonds in the above structure. B. Is this molecule water soluble (hydrophilic) or fat soluble (hydrophobic)? C. If 1500 mg of resveratrol is required for a person who weighs 45 kg, determine the appropriate dose for someone who weighs 155 lbs.

Answer 1

| Resveratrol HO OH H Since, O difference has electronegaturity + o H bond is polar. ® Solubility of resveratrol is water insoluble due to large non-polar fart. It is fat soluble because fats are also non-polar. Basic principle of solubility like dissolve like. 1500mg of resveratrol required I Es 45 kg person. : 1 lb = 0.454 kg - 155 lbs = 0.454 x 155 kg. = 70.37kg . 45 kg person requires 1500mg . 70.87 kg 1500 x 70.37 mg = 2345.67mg 45

2.345 g (: 1000rag=1g) Thus the person weighing 155 lbs requires (2.345 g) of resveratrol.