Homework Answers
Solution: Option B is the right answer. The CFTR(Cystic fibrosis transmembrane conductance regulator) is a membrane protein which is a chloride channel classified under ABC super family. The CFTR mutation affects the long arm of chromosome 7 at position q31.2. Approximately the two third of cystic fibrosis can be caused by the deletion of phenylalanine at 508th position. Amino acid Glycine at 551th position if mutated to Aspartic acid accounts for 5 percent of Cystic fibrosis conditions.
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The location for the gene for cystic fibrosis is 7q31.2. This means that the gene is...
Mutations in the CFTR gene result in cystic fibrosis in humans, a condition in which abnormal...
Mutations in the CFTR gene result in
cystic fibrosis in humans, a condition in which abnormal secretions
are present in the lungs, pancreas, and sweat glands. In the effort
to positionally clone the CFTR gene, the gene was mapped to a
region of 500 kb on chromosome 7 containing three candidate genes.
Using your knowledge of the disease symptoms, how would you
distinguish between the candidate genes to decide which is most
likely to encode the CFTR gene?
4. The CFTR gene is carried on human chromosome 7, an autosome. A recessive mutation in...
4. The CFTR gene is carried on human chromosome 7, an autosome. A recessive mutation in CFTR is the cause of cystic fibrosis disease. A female who doesn't have cystic fibrosis has a child with a man who also doesn't have the disease. Their first child has cystic fibrosis. What is the probability their second child will have the disease? A. 0 (definitely will not have it) B. 1/4 C. 1/2 D. 3/4 E. 1 (definitely will have it)
sean and michelle are healthy, but their daugher molly was recently diagnosed with cystic fibrosis. Guess...
sean and michelle are healthy, but their daugher molly was recently diagnosed with cystic fibrosis. Guess the genotype of the parents for cystic fibrosis disease? a. sean and michele are heterozygous for cystic fibrosis allele, they are carreirs b. sean and michele are homozygous for cystic fibrosis allele, but the disease will be manifested later in their life c. sean does not have the cystic fibrosis allele, he is homozygous for the healthy variant of the gene, michell is the...
You must try to answer both questions: Cystic fibrosis (CF) is an inherited disorder that causes...
You must try to answer both questions: Cystic fibrosis (CF) is an inherited disorder that causes severe damage to the lungs, the digestive system and other organs within the body. CF affects cells that produce thin and slippery mucus and cause the secretions to become sticky and thick. CF is caused by a deletion mutation on chromosome 7. In order for a child to have cystic fibrosis they must inherit a defective gene from each of his/her parents a) Rob...
The most common mutation occuring in people with cystic fibrosis is the loss of a single...
The most common mutation occuring in people with cystic fibrosis is the loss of a single amino acid (phenylalanine) at position 508 of the protein. This mutation O a. is a point mutation b. is an single nucleotide polymorphism c. is a deletion of 3 nucleotides d. in an insertion of a single nucleotide e. is a chromosomal rearrangement → Moving to another question will save this response. In Concience in 5 min you. For ence ne
1) For the exercise using Map Viewer to Determine the Chromosome Location of the fwa-1 Gene:...
1) For the exercise using Map Viewer to Determine the Chromosome Location of the fwa-1 Gene: On which chromosome is the FWA gene located? 2) For the exercise using Map Viewer to Determine the Chromosome Location of the fwa-1 Gene: Which gene is closest to the amplicon? 3) Determine the size of the FWA gene, including the introns,
Stion 6: Cystic fibrosis is a hereditary lung disease that usually results in premature death. It...
stion 6: Cystic fibrosis is a hereditary lung disease that usually results in premature death. It can e inherited if both parents are carriers of an abnormal gene. The CF gene was identified in 1989. The prevalence of this gene in people of European ancestry is 1 in 25, or 4%. The CF20m is a test that is to detect harmful mutations of the CF gene. The sensitivity of the CF20m test is 0.90, and its specificity is 0.98. A...
stion 6: Cystic fibrosis is a hereditary lung disease that usually results in premature death. It...
stion 6: Cystic fibrosis is a hereditary lung disease that usually results in premature death. It can e inherited if both parents are carriers of an abnormal gene. The CF gene was identified in 1989. The prevalence of this gene in people of European ancestry is 1 in 25, or 4%. The CF20m is a test that is to detect harmful mutations of the CF gene. The sensitivity of the CF20m test is 0.90, and its specificity is 0.98. A...
QUESTION 9 5 pe If the characteristic depicted in the pedigree below is rare and subject...
QUESTION 9 5 pe If the characteristic depicted in the pedigree below is rare and subject to complete penetrance, it is likely to be X-linked recessive? 5 6 7 -OOO No, because individuals ll-2 and 11-4 are not affected No, because individuals 111-4 and III-6 are not affected Yes, because individuals III-4 and III-6 are not affected Yes, because only females are affected in generation 11 1. The gene for cystic fibrosis (normal dominant allele CF and abnormal recessive allele...
Arterial blood gas case study 1 A 14-year-old girl with cystic fibrosis has complained of an...
Arterial blood gas case study 1 A 14-year-old girl with cystic fibrosis has complained of an increased cough productive of green sputum over the last week. She also complained of being increasingly short of breath, and she is noticeably wheezing on physical examination. Arterial blood was drawn and sampled, revealing the following values: pH 7.30 pCO2 50 mm Hg pO2 55 mm Hg Hemoglobin - O2 saturation 45 % [HCO3-] 24 meq / liter Questions: 1....
Mutations in the CFTR gene result in
cystic fibrosis in humans, a condition in which abnormal secretions
are present in the lungs, pancreas, and sweat glands. In the effort
to positionally clone the CFTR gene, the gene was mapped to a
region of 500 kb on chromosome 7 containing three candidate genes.
Using your knowledge of the disease symptoms, how would you
distinguish between the candidate genes to decide which is most
likely to encode the CFTR gene?
You must try to answer both questions: Cystic fibrosis (CF) is an inherited disorder that causes severe damage to the lungs, the digestive system and other organs within the body. CF affects cells that produce thin and slippery mucus and cause the secretions to become sticky and thick. CF is caused by a deletion mutation on chromosome 7. In order for a child to have cystic fibrosis they must inherit a defective gene from each of his/her parents a) Rob...
The most common mutation occuring in people with cystic fibrosis is the loss of a single amino acid (phenylalanine) at position 508 of the protein. This mutation O a. is a point mutation b. is an single nucleotide polymorphism c. is a deletion of 3 nucleotides d. in an insertion of a single nucleotide e. is a chromosomal rearrangement → Moving to another question will save this response. In Concience in 5 min you. For ence ne
stion 6: Cystic fibrosis is a hereditary lung disease that usually results in premature death. It can e inherited if both parents are carriers of an abnormal gene. The CF gene was identified in 1989. The prevalence of this gene in people of European ancestry is 1 in 25, or 4%. The CF20m is a test that is to detect harmful mutations of the CF gene. The sensitivity of the CF20m test is 0.90, and its specificity is 0.98. A...
stion 6: Cystic fibrosis is a hereditary lung disease that usually results in premature death. It can e inherited if both parents are carriers of an abnormal gene. The CF gene was identified in 1989. The prevalence of this gene in people of European ancestry is 1 in 25, or 4%. The CF20m is a test that is to detect harmful mutations of the CF gene. The sensitivity of the CF20m test is 0.90, and its specificity is 0.98. A...
QUESTION 9 5 pe If the characteristic depicted in the pedigree below is rare and subject to complete penetrance, it is likely to be X-linked recessive? 5 6 7 -OOO No, because individuals ll-2 and 11-4 are not affected No, because individuals 111-4 and III-6 are not affected Yes, because individuals III-4 and III-6 are not affected Yes, because only females are affected in generation 11 1. The gene for cystic fibrosis (normal dominant allele CF and abnormal recessive allele...
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