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In order to exert their effects on a cell, both insulin and glucagon bind to a...

In order to exert their effects on a cell, both insulin and glucagon bind to a receptor in the cell membrane. Why is a receptor necessary? (ie why do the hormones not simply enter the cell?)

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Answer #1

some hormones can not cross the cell membrane. they attach to the receptors on the cell membrane and produce their action.

for a substance to pass through cell membrane, it has to be lipid-soluble. only thyroid hormone and steroid hormones have intracellular receptions. other hormones can not pass through the cell membrane. so they have receptors on the cell membranes and they act through second messengers.

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