Question

3) For the following multi-step synthesis. Provide the reagents needed for each step of the sequence and then write a paragraph that explains what has occurred overall synthetically and why this elaborate strategy is needed. HC 5- 0 HAC NMgBr

Answer 1

-3) Boys TO DM. dinashyl sily NaCN kCN, HQ HỌ | 7 || Teutbe chloride TEA (NE) Dem, rf Mech, st.' Ñ a a MgBr ones Etrg Br Y theolit H2O% -780, Diethyl ether STHA sus amper Tycholysis HO s to There is of nucleophile cas a nucleophilie attack at carbonyl group (electrophilie center det to give the product 2! Now 'On group g 2 can be resily protected with fert-butyl dimethyl Silyl chloride using mild' base triethylamine to give the compound Uz. Now there is a grignand reaction taking place at can group g compound 3 and eth eng attack as the Astrong nucleophile at ebet sophilic center 9 - can group', to give the product 4. Finally compound '4 is subjected to hydrolysis to give the final product 5.