Question

Read the paper's abstract and discussion below. Answer these questions about the particular viral strategy in the paper: 1. Does this allow the virus to evade the innate or adaptive immune response? Of adaptive, Is It humoral or cell-mediated?) 2. How does the virus do this? 3. What viral protein is involved (if any? 4. What specific step in host defense is affected? 5. What is the result? Inhibition of the Interferon-Inducible Protein kinase PKR by HCVE2 Protein, Deborah R. Taylor, Stephanie Science 02 Jul 1999: Vol. 285, Issue 5424, pp. 107.110 SH 1. Patrick R. Romano, Glen N. Barber, Michael M C. Lai. Abstract Most isolates of hepatitis C virus (HCV) Infections are resistant to interferon, the only available therapy, but the mechanism underlying this resistance has not been defined. Here it is shown that the HCV envelope protein E2 contains a sequence Identical with phosphorylation sites of the Interferon-inducible protein kinase PKR and the translation initiation factor el F2, a target of PKR E2 inhibited the case activity of PKR and blocked its inhibitory effect on protein synthesis and cell growth. This interaction of E2 and PKR may be one mechanism by which HCV circumvents the antiviral effect of interferon Discussion Our results suggest that the protein of HCV genotype 1 binds to and this PKR in vitro and does sin mammalian cells and yeast because of sequence homology to the PKR and if a phosphorylation sites. These effects correlate with the relative resistance of HCV genotype 1 to F. Thus. HCV may have evolved a two devetattack namely NS5A and 2 on PKR to interfere with Factor Although the NSSA PKR interaction may contribute to development of resistance in the 20the E2PKR Interaction may account for the resistance of HCV genotypes 1 and 15. The combined effects of NSSA E2 may explain t H irections become persistent. Another potential outcome of PKR inition is the promotion of cell growth, which may contre to w atertocellular carro The P o ctivity of HCV proteinamaanish ed the presence of the leader sec uesting that 2 and interact whe re the ERAER PER bescribed shares homology with and recognizes the same substrate 2012. m ondotetor

Read the paper's abstract and discussion below. Answer these questions about the particle viral strategy in the paper

a) Does this allow the virus to evadecthe innate or adaptive immune system( if adaptative, is it humoral or cell mediated

b) How does the virus do this

c) What viral protein is involved, if any

d) What dpecific step in host defensevis affected

e) what is the result