A toxin that binds specifically to voltage-gated sodium channels in axons would be expected to _______
A toxin that binds specifically to voltage gated sodium channels in axons would be expected to prevent the depolarization phase of the action potential.
A toxin that binds specifically to voltage-gated sodium channels in axons would be expected to _______
How would you alter sodium and/or potassium voltage-gated channels to preserve their dependence on voltage, but eliminate action potentials? Effect of altering Na/K channels
Name ore toxin that affects each of the following targets: a. Nicotinic acetylcholine receptors 7. Voltage-gated sodium channels b. c. Metabolic acidosis d. GABA receptors
choices for A: Na+/K+ pumps, voltage gated K+ channels, voltage gated Ca+ channels, voltage gated Na+ channels choices for B: bidirectionally, unidirectionally choices for C: Na+/K+ pumps, voltage gated K+ channels, voltage gated Ca+ channels, voltage gated Na+ channels choices for D: Na+/K+ pumps, voltage gated K+ channels, voltage gated Ca+ channels, voltage gated Na+ channels Consider this graph illustrating the generation of an action potential across the plasma membrane of a stimulated neuron. +40 ACTION POTENTIAL plasma membrane potential...
3. Many neurons contain "delayed K channels". Like voltage-gated Nat channels, these voltage-gated K+ channels open in response to a rise in membrane potential and then undergo inactivation. However, opening of the voltage-gated K channels lags behind opening of the voltage-gated Na channels. a) Why does neuronal function require the voltage-gated K channels to open more slowly than the voltage-gated Na channels? b) Compared to a neuron that lacks voltage-gated K channels, what differences would you expect in the shape...
Assume a mutation of the gene coding for the voltage-gated sodium channel resulted in channels that do not have the ball and chain part of the protein. Which of the following would you expect to see? a. A change in the ion selectivity of the channel of the mutated channels, allowing ions other than sodium to move through it. b. A change in the voltage sensitivity of the channel so that it does not open until more depolarized voltages. c....
Voltage-gated Na channels exist in three distinct conformations in axons because Answers A-D A they assume an inactivated conformation shortly after opening, which ensures that the action potential cannot move backwards toward the cell body. B they change conformation when binding Nat and transporting it to the opposite side of the membrane before releasing it outside the cell. C they respond to ligand binding, mechanical stress, or changes in voltage. D they assume different conformations as ATP is bound and...
Which choice represents transport proteins in a neuron? a. Voltage-gated channels and passive transporters b. Passive transporters and sodium-potassium cotransporters c. Sodium-potassium cotransporters, passive transporters, and voltage-gated channels d. Voltage-gated channels and passive transporters e. Sodium-potassium cotransporters and voltage-gated channels
Dendrotoxins, produced by the mamba snake, are inhibitors of the voltage-gated K+ channels. What phase of the action potential would this toxin affect? How would it affect ion permeability during this phase? How would ion movement be affected?
An action potential does not move back wards in the axon because.. a.Voltage-gated sodium channels behind the action potential are inactivated. b. Potassium leak channels no longer let potassium ions through c. Voltage-gated sodium channels are open d. Mechanically-gated channels prevent outflow of sodium e. Voltage-gated potassium channels are closed
The Japanese pufferfish produces a highly potent neurotoxin called tetrodotoxin (TTX). TTX binds to voltage-gated sodium channels, preventing them from opening. Ingestion of TTX causes numbness of the lips and tongue, followed rapidly by weakness, loss of coordination, and a sensation of limpness and weakness throughout the body. Relatively small doses of TTX can kill a person.How exactly do you think TTX kills?