What is the major machinery that decides whether a cell progresses through the G1 checkpoint, and how dos theis machinery implement these decisions?
from G1 to S checkpoints-
1) size of cell- cell has to big in size.
2) enough amount of nutrient is present.
3) got some positive signals to divide from neighbouring cells.
4) DNA integrity- whether the DNA has any damage or not.
during G1 to S phase transition transcription factor RB binds to E2F and inhibit the synthesis of S phase gene transcription. when RB is phosphorylated with cyclin CDK complex it will no longer be associated with E2F factor and E2F will start the synthesis of S phase gene transcription. p21, p27 and p57 binds with cyclin CDK complex and inactivates it.
What is the major machinery that decides whether a cell progresses through the G1 checkpoint, and...
Describe how cell cycle control is related to cancer. Include a description of the G1 checkpoint and signal transduction.
A cell in G1 contains 24 picograms of DNA. If that cell goes through a round of mitotic division, how much DNA will be in a resulting daughter cell?
1. Damaged DNA is discovered during the G1 checkpoint. How does p53 react, and what are the possible results? 2. If S phase checkpoints detect nucleotides deficit, what happens to the dividing cell and the cell cycle? 3. What three conditions may be detected during the G2 checkpoints, and what are the two possible results if there is inadequate DNA or spindle fibers? 4. What two conditions are checked during the metaphase checkpoint? What happens if the cell “passes” the...
QUESTION 7 If you inject a G1 cell that contains 36 chromosomes with a G2/M cyclin, what would happen? (hint - look at slide with cell fusion experiments) The G1 cell would complete mitosis with daughter cells that have 18 chromosomes each The G1 cell would enter mitosis but arrest at the spindle checkpoint because the chromosomes were not properly replicated The G1 cell would complete mitosis with daughter cells that have 36 chromosomes each The G1 cell would go...
Cell & Molecuar Biology: Cell-Division Cycle What signals feed into the G1-to-S transition? Name one controller for this transition. Describe one target of this controller and how the controller regulates that target. (Please be specific)
different types 1. Life begins as a single cell but turns into 2. What is melanoma? 3. What genetic mutation causes melanoma? Look at the Cell Cycle diagram below and talk about what happens ateach of the Interphase parts: INTERPHASE (DNA synthesis) Cytokinesis MITOTIC (M) PHASE 4. Summarize G1: 2. What does the G1 checkpoint insure? 5. Summarize S phase 6. Summarize G2 7. What is GO stage? 8 How do Growth Factors infuence the cell cyo 3. What are...
How do the events that occur in interphase prepare the cell for prophase? What "cellular machinery" needs to be in place before prophase?
QUESTION 1 A gene that encodes a protein that stimulates progression of the cell cycle is known as a proto-oncogene. True False QUESTION 2 Cytokinesis occurs after which stage or phase of the cell cycle? a. G2 b. S c. G0 d. G1 e. M phase QUESTION 3 During cell-cycle checkpoints, protein kinases known as CDKs phosphorylate target proteins only when they associate with a cyclin. True False QUESTION 4 During mitosis, many of the spindle fibers attach to chromosomes...
Name: 2. You cell cycle. Describe this process, including DNA replication (when is occurs and what is produced), The major portions of the cell cycle and what those portions are divided into. For the cell division process you should use a chromosome number of 2N-4, instead of the real human chromosome number of 2N-46 have a broken leg and you realize that in order to heal your body needs to proceed through the
Name: 2. You cell cycle. Describe this...
You are a studying the progression of cells through the cell cycle. You are particularly interested in the role of the APC, which in a ubiquitin E3 ligase, in the control of the metaphase cyclin (cyclin B) and the timing of events. To look at this you start by synchronizing your cells in G1 and examining the levels of Cyclin B over time. The APC usually works on cyclin B during anaphase. RBX57 is a substrate for Cylcin B/CDK2. Given...