The following peptide fragment is part of an alpha
helix found inside the cell membrane as part of a transmembrane
protein. Where will the following peptide fragment (shown as it
would exist inside the body at pH 7.4) more likely be found.
choice 1
on the interior of the cell membrane
choice 2
on the intracellular side of the cell:
choice 3
or on the extracellular side of the cell.
Be sure to discuss why you choose the areas you selected by stating
what the environment is like in that area of the cell.
Explain?
Homework Answers
The peptide shown in the diagram exhibits histidine amino acid, which is an aromatic amino acid and takes part in various catalytic reaction. It interacts with several metalloproteins that are present inside the transmembrane or cytoplasm. Option 2 looks more correct. As it is positively charged aromatic amino acid it will not affect the near environment due to hydrophilic lipid bilayers.
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