Can you predict an undesirable side reaction that might occur using ethanol as a solvent that...
Can you predict an undesirable side reaction that might occur using ethanol as a solvent that
would not occur if we used THF as a solvent in an Sn2 reaction
Homework Answers
THF is a polar aprotic solvent which stabilize the transition state of SN2 reaction .Hence, it is used in SN2 reaction.
Changing the solvent from THF to ethanol will greatly affect the product and mechanism.
Ethanol is a polar protic solvent which stabilize the transition state of SN1 reaction . Hence , it is used in SN1 reaction.
It means changing the solvent from THF to ethanol will get us SN1 reaction instead of SN2 reaction . In SN2 we get high percentage of one chiral product but in SN1 we get equal amount of enantiomers and the product become racemic (not chiral.)
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Can you predict an undesirable side reaction that might occur
using ethanol as a solvent that...
1-) What is the difference between SN1 and SN2 reactions? Please list at least three different...
1-) What is the difference between SN1 and SN2 reactions? Please list at least three different factors for each reaction type. Also provide an example for each type with detailed arrow-pushing mechanism. 2-) Ethanol is not usually a solvent used for SN2 reactions – why not? Describe an undesirable side reaction that might occur using ethanol as a solvent that would not occur if THF was used as the solvent.
Please give detailed answers to the pre and post lab questions. Thank you! NUCLEOPHILIC DISPLACEMENT- FORMATION...
Please give detailed answers to the pre and post lab questions.
Thank you!
NUCLEOPHILIC DISPLACEMENT- FORMATION OF AN ETHER BY AN SN2 REACTION Bond formation by use of an SN2 reaction is very important for organic and biological synthesis. Many new bonds formed make use of this versatile reaction pathway. In this reaction, one partner is the nucleophile and the other partner is the electrophile. The electrophile will have a leaving group that will be lost in the reaction. In...
Why can 95% ethanol be used as a solvent in the synthesis of 2-butoxynaphthalene? I thought...
Why can 95% ethanol be used as a solvent in the synthesis of 2-butoxynaphthalene? I thought that for an Sn2 mechanism only aprotic solvents can be used for the synthesis?
4. The choice of solvent for the reaction below can have a drastic effect on the...
4. The choice of solvent for the reaction below can have a drastic effect on the rate. If we run one reaction in hexane and one reaction in THF, which one would you expect to go faster? Why? If you wanted the reaction to go even faster, what could you add to the reaction mixture? OLI LIHMDS pre HNOS er en Ph solvent Ph
if in project 7.1, 100% ethanol was used as the reaction solvent instead of diethyl ether,...
if
in project 7.1, 100% ethanol was used as the reaction solvent
instead of diethyl ether, what would the product(s) of the reaction
be? be sure to explain the formation of your predicted products.
2. If in Project 7.1, 100% ethanol was used as the reaction solvent instead of diethyl ether, what would the product(s) of the reaction be? Be sure to explain the formation of your predicted products. MgBr HOCH CH3
We begin with the surmise that the nucleophilic substitution reactions can occur only by one of...
We begin with the surmise that the nucleophilic substitution reactions can occur only by one of two mechanisms: Sn1 solvolysis: three-step mechanism R-X slow, R® + to R® + ROH fast , ROM R' H. R-O + R'OH fast , ROR' + R- SN2: one-step mechanism R-X + Nuc slow, Nuc-R + x Begin by answering the three questions below. If you don't understand what's up, please ask! 1. Write out the rate law for the above Sn1 reaction and...
6 QUESTION 6 (1 point) Which of the following solvent(s) can be used for the Grignard...
6 QUESTION 6 (1 point) Which of the following solvent(s) can be used for the Grignard reaction? methanol, ethanol, water, diethyl ether, THF all of them in the list methanol and ethanol diethyl ether and THF water Click Save and Submit to save and submit. Click Save All Answers to save all answers F3
for the reaction: acetaminophen + (NaOH/EtOH note: etoh is ethanol) and butyl iodide ---------------> 4-butoxyacetanilide a)...
for the reaction: acetaminophen + (NaOH/EtOH note: etoh is ethanol) and butyl iodide ---------------> 4-butoxyacetanilide a) The first step in this reaction is to reflux acetaminophen in a NaOH/EtOH solution, followed by the addition of butyl iodide. What is the purpose of using the NaOH/EtOH solution? Would the SN2 reaction still occur if the first step was not completed? Why or why not? b) Upon completion of the reaction (before filtration), an additional 4.0 mL of 1.0 M NaOH/EtOH was...
1. Predict the products of the following reactions (18 points, 3 each) Catalytic KOH methanol/water solvent...
1. Predict the products of the following reactions (18 points, 3 each) Catalytic KOH methanol/water solvent Catalytic KOH methanol/water solvent Catalytic KOH methanol water solvent Catalye KOH. 1 equivalent NaOCH.CH ethanol solvent I equivalent NaOCH.CH ethanol solvent 2. Write the product of the following reaction and the full mechanism by which it is formed. Clearly show which steps are reversible and which one step is irreversible. (8 points). 1 equivalent NaOCH CH3 cthanol solvent + excess 3. Circle the most...
hypothesize why a tertiary alcohol is a good solvent for an sn2 reaction where CsF is...
hypothesize why a tertiary alcohol is a good solvent for an sn2 reaction where CsF is the nucleophile and iodide is the leaving group there are various electrophiles that iodide is leaving from who's identities don't seem to matter. from everything I've learned up to now protic solvents are NOT good solvents for sn2 rxns. there have been numerous articles on a research project where 18F is being used for radiolabeling in biological systems and they used tert-amy-alcohol for the...
Please give detailed answers to the pre and post lab questions.
Thank you!
NUCLEOPHILIC DISPLACEMENT- FORMATION OF AN ETHER BY AN SN2 REACTION Bond formation by use of an SN2 reaction is very important for organic and biological synthesis. Many new bonds formed make use of this versatile reaction pathway. In this reaction, one partner is the nucleophile and the other partner is the electrophile. The electrophile will have a leaving group that will be lost in the reaction. In...
4. The choice of solvent for the reaction below can have a drastic effect on the rate. If we run one reaction in hexane and one reaction in THF, which one would you expect to go faster? Why? If you wanted the reaction to go even faster, what could you add to the reaction mixture? OLI LIHMDS pre HNOS er en Ph solvent Ph
if
in project 7.1, 100% ethanol was used as the reaction solvent
instead of diethyl ether, what would the product(s) of the reaction
be? be sure to explain the formation of your predicted products.
2. If in Project 7.1, 100% ethanol was used as the reaction solvent instead of diethyl ether, what would the product(s) of the reaction be? Be sure to explain the formation of your predicted products. MgBr HOCH CH3
We begin with the surmise that the nucleophilic substitution reactions can occur only by one of two mechanisms: Sn1 solvolysis: three-step mechanism R-X slow, R® + to R® + ROH fast , ROM R' H. R-O + R'OH fast , ROR' + R- SN2: one-step mechanism R-X + Nuc slow, Nuc-R + x Begin by answering the three questions below. If you don't understand what's up, please ask! 1. Write out the rate law for the above Sn1 reaction and...
6 QUESTION 6 (1 point) Which of the following solvent(s) can be used for the Grignard reaction? methanol, ethanol, water, diethyl ether, THF all of them in the list methanol and ethanol diethyl ether and THF water Click Save and Submit to save and submit. Click Save All Answers to save all answers F3
1. Predict the products of the following reactions (18 points, 3 each) Catalytic KOH methanol/water solvent Catalytic KOH methanol/water solvent Catalytic KOH methanol water solvent Catalye KOH. 1 equivalent NaOCH.CH ethanol solvent I equivalent NaOCH.CH ethanol solvent 2. Write the product of the following reaction and the full mechanism by which it is formed. Clearly show which steps are reversible and which one step is irreversible. (8 points). 1 equivalent NaOCH CH3 cthanol solvent + excess 3. Circle the most...
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