For determining the toxicity of different compounds, the concept of LD50, the lethal dose for 50% of test subjects is used. The LD50 in rats for caffeine is 192mg per 1 kg of body weight. Assuming the same LD50 for humans.For a 180-lb person, calculate the number of cups of coffee that must be ingested to provide the LD50 for caffeine if one cup is 12 fluid ounces and there is 100mg of caffeine per 6 fluid ounces of drip brewed coffee.
Per 1 kg ---> 192 mg
180 lb person = 81.6466 kg ( 1 lb = 0.453 kg) ------> == 15676.1472 mg of caffeine is lethal dose (LD50)
100 mg of caffeine ---> 6 fluid ounces
15676.1472 mg of caffeine ---> ?? = 15676.1472 mg x 6 fluid ounce/100 = 94056.8832/100 = 940.568832 fluid ounces
12 fluid ounces = one cup
940.568832 fluid ounces = 940.608 /12 = 78.380736 cups = 78 cups (nearly)
The number of cups of coffee that must be ingested to provide the LD50 for caffeine = 78 cups
For determining the toxicity of different compounds, the concept of LD50, the lethal dose for 50%...
3. The Lethal dose (LD50) is the amount of an ingested substance that will kill 50 percent of the test sample. It is usually expressed in mg of substance per kg of body weight (mg/kg). FD&C Blue Dye #1 has an LD50 of 300 mg/kg. Determine the mass of blue dye that would be required to reach the LD 50 for a 105 lb person.
3. The Lethal dose (LD50) is the amount of an ingested substance that will kill 50 percent of the test sample. It is usually expressed in mg of substance per kg of body weight (mg/kg). FD&C Blue Dye #1 has an LD50 of 300 mg/kg. Determine the mass of blue dye that would be required to reach the LD 50 for a 105 lb person.
The LD50 for caffeine is 192 mg/kg. How many cups of coffee would provide a lethal dose for a 150 lbs person? ( 1 cup contains 92 mg of caffeine and 2.21 lbs =1 kg)
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