Question

1. what are three different reactions of gluconeogenesis from glycolysis?

2. what are regulation of metabolic pathways of glycolysis and citric acid cycle?

3. Glycolysis: what kind of molecules will be activators and what kind of molecules will be inhibitors?

4. what are major differences of glucolysis vs glyconeogenesis?

Answer 1

1.the reactions catalysed by pyruvate kinase, phoshofructokinase and hexokinase/ glucokinase.

2. Regulation of glycolysis

_ Hexokinase: feedback inhibited by glucose-6-phosphate.so phoshorylation of glucose is inhibited.

_ phosphofructokinase: ATP and citrate inhibit phoshofructokinase.

AMP activates it.

_pyruvate kinase: inhibitted by Acetyl co A,. Fatty acids

Activated by fructose -1,6-bis phosphate

Regulation of citric acid cycle:

3. Glycolysis is the break down of glucose.

If glucose level is increased in blood it causes increased glycolysis. Insulin hormone will be secreted in large amounts to activate glycolysis.

If glucose level is less in blood glycolysis is inhibited by hormones like glucagon.

4. Glucolysis versus gluconeogenesis