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Why can Koch’s Postulates NOT be used to determine causative agent of AIDS? How was it...

  1. Why can Koch’s Postulates NOT be used to determine causative agent of AIDS? How was it determined that HIV causes AIDS?
  2. Watch the video “HIV Life Cycle” at https://www.biointeractive.org/classroom-resources/hiv-life-cycle. List 3 virulence factors of HIV and explain in which stage of pathogenesis (exposure, adhesion, invasion, infection, and transmission) the virulence factors are used.
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Answer #1

Many viruses do not cause illness in all infected persons, a requirement of postulate #1. Poliovirus, which causes paralytic disease in about 1% of those infected. Infection with the same virus may lead to markedly different diseases, while different viruses may cause the same disease. Postulates #2 and #3 cannot be fulfilled for viruses that do not replicate in cell culture, for that a suitable animal model has not been identified.

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