Question

While the classic synapse is one between an axon and a dendrite, axons can create synapses with any part of a neuron. The major kinds are axo-somatic (axon synapses with the soma of the post-synaptic neuron), axo-dendritic (the classic synapse), and axo-axonic (creates a synapse with the post-synaptic neurons axon). How do you think location of these synapses would affect the generation of an action potential?

Answer 1

Action potential is the determinant force which excites or inhibit to create a act of synapses. The three major synapses integrate electrophysiological signals to balance actions and reactions through LFP local field potential at particular location to make a closed network circuit. The LFP neuronal assemblies for various synapse models can be further simplified to generate LSA linear source approximation to find analytical expression with their extracellular potential.

Axo-Somatic is responsible for morphological features that drives the cellular signalling to co-ordinate  spatio-temporal plasticity with Vesicular glutamate transporter that helps calyx of held. The classic synapse are vital constituent which foresee active electrical signals from an input as action potential to an output. On this criterion of logical operation such as AND/OR/XOR it builds a algorithm to network cortical abilities and evolve behaviors. Axo-Axonic has the lowest action potential and strategically plays role in inhibition to control output. Thus location of synapse with various signalling neuro-transmitters generation of action potential is taken care as a means of the networking principle.