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Question 1. Define the terms transcriptome and proteome. Will the (a) genome, (b) transcriptome, and (c)...

Question 1. Define the terms transcriptome and proteome. Will the (a) genome, (b) transcriptome, and (c) proteome of a mouse heart differ from its pancreas? Will the (a) genome, (b) transcriptome, and (c) proteome of the pancreas of identical twin mice differ if one developed cancer and the other did not? Explain your answers.

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1. Transcriptome: The total molecules of RNAs expressed from the genes of a cell, tissues or the complete organism.

Proteome: The set of all the proteins expressed by the genome of a cell, tissue or an organism.

2. The genome of mouse heat is same as that of pancreas, but the RNAs expressed for the heart cells may differ from that of pancreas, to produce different proteins in each of them. Hence the trancriptome and proteome of the mouse heart and pancreas differ from each other.

3. Identical twins are genetically identical, so they have the same genome, transcriptome, and proteome. But if one of them develops cancer, it causes alteration at the gene level leading to change in the trascript (RNAs) expressed and hence alteration in the proteins synthesized. due to the change in that coding mRNA. Therefore, the genome, transcriptome, and the proteome of the identical twin mouse will differ from the other if it develops cancer in pancreas.

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