What are the protein targets in glioma cell lines
What are the protein targets in glioma cell lines
Homework Answers
BAG3 (BCL2 Associated Athanogene 3) is a member of the BAG family of HSC/HSP70 co-chaperones. Studies were done by Festa et al., 2011 has shown that this protein is overexpressed in glioma and could be targeted for therapy. Downregulation of BAG3 resulted in increased sensitivity to apoptosis in in-vitro and in-vivo model of studies.
Reference
Festa M., Del Valle L., Khalili K., Franco R., Scognamiglio G., Graziano V., De Laurenzi V., Turco M.C., Rosati A. BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy. Am. J. Pathol. 2011;178:2504–2512. doi: 10.1016/j.ajpath.2011.02.002
D. Antiviral E. Antifungal 14. What type of drug is Metronidazole? A. Antibacterial, targets cell wall...
D. Antiviral E. Antifungal 14. What type of drug is Metronidazole? A. Antibacterial, targets cell wall synthesis B. Antibacterial, targets ribosomes/protein synthesis C. Antibacterial, other D. Antiviral E. Antifungal 15. What type of drug is Daptomycin? A. Antibacterial, targets cell wall synthesis B. Antibacterial, targets ribosomes/protein synthesis C. Antibacterial, other D. Antiviral E. Antifungal 16. What type of drug is Amphotericin B? A. Antibacterial, targets cell wall synthesis B. Antibacterial, targets ribosomes/protein synthesis C. Antibacterial, other
1) Antimicrobial X targets a specific protein in the cytoplasm of the bacterial cell, causing the...
1) Antimicrobial X targets a specific protein in the cytoplasm of the bacterial cell, causing the bacteria to stop growing, but does not kill them. A few bacteria start to grow in the presence of antibiotic X. Analysis of the bacteria that can now grow shows that they have changed the shape of the target for antimicrobial X. What conclusion can be made? a) The change in shape of the target for antimicrobial X had no effect on the effectiveness...
Label the image to review major targets of drugs acting on bacterial cells. Cephalosporins Protein synthesis...
Label the image to review major targets of drugs acting on bacterial cells. Cephalosporins Protein synthesis inhibitors acting on ribosomes Cell membrane Sulfonamides (sulfa drugs) Cell wall inhibitors Penicillins Polymyxins Erythromycin Aminoglycosides Quinolones Folic acid synthesis DNA/RNA Rifampin
Antibiotic A: 0.5 kDa protein, targets peptidoglycan Antibiotic B: 20 kDa protein, targets peptidoglycan Antibiotic C:...
Antibiotic A: 0.5 kDa protein, targets peptidoglycan Antibiotic B: 20 kDa protein, targets peptidoglycan Antibiotic C: Cationic Antimicrobial Peptide (CAMP) Antibiotic D: Targets lipopolysaccharide With some more searching, you found the following results in your notebook. Percent Survival Percent Survival Antibiotic Antibiotic Control Control protoplast C. difficile protoplast Bacteria S. aureus E. coli V. cholera C. difficile S. aureus E. coli V. cholera Bacteria Percent Survival Percent Survival Antibiotic Antibiotic Control Control E.coli S. aureus Bacteria S. aureus E. colis...
When the Rb protein is phosphorylated it allows the cell to progress through the__checkpoint. OG1 OM...
When the Rb protein is phosphorylated it allows the cell to progress through the__checkpoint. OG1 OM os OG2 Question 8 2 pts What is the function of cyclin-CDK complexes? They prevent DNA replication from occurring so that a cell cannot go through the cell cycle The function as growth factors which tell the cell to divide when necessary They prevent a cell from being able to enter meiosis They phosphorylate cellular targets which allows the cell to progress to the...
Retroviruses are typically used for gene therapy approaches. The development of the retroviral packing cell lines...
Retroviruses are typically used for gene therapy approaches. The development of the retroviral packing cell lines was critical to the development of retroviruses as vectors for gene therapy. Explain how packing cell lines help to overcome the following problems a) In order to fir therapeutic genes into retroviruses some of the viruses’ essential genes must be replaced by the therapeutic genes. How then, is the viruses able to multiply to produce the viral particles necessary to infect targets? b) Wild-type...
If the cell needs to synthesize a protein to build its cell membrane what is the...
If the cell needs to synthesize a protein to build its cell membrane what is the process that the mRNA transcript needs to go through? (explain all steps)
Drag the appropriate labels to their respective targets. Reset Help Cell body Satellite cell Peripheral axon...
Drag the appropriate labels to their respective targets. Reset Help Cell body Satellite cell Peripheral axon Central axon Schwann cell NEUROGLIAL CELL TYPE FUNCTION • Myelinate certain axons in the PNS • Surround and support cell bodies
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycl...
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycle. Why doesn't this Cdk activate G1-, S-, G2-, and M-phase proteins all at the same time? B. Please describe how cell death by apoptosis can play a beneficial role in the body's healthy growth. C. For a cell starting in G1, place the following cell cycle events in...
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycl...
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycle. Why doesn't this Cdk activate G1-, S-, G2-, and M-phase proteins all at the same time? B. Please describe how cell death by apoptosis can play a beneficial role in the body's healthy growth. C. For a cell starting in G1, place the following cell cycle events in...
D. Antiviral E. Antifungal 14. What type of drug is Metronidazole? A. Antibacterial, targets cell wall synthesis B. Antibacterial, targets ribosomes/protein synthesis C. Antibacterial, other D. Antiviral E. Antifungal 15. What type of drug is Daptomycin? A. Antibacterial, targets cell wall synthesis B. Antibacterial, targets ribosomes/protein synthesis C. Antibacterial, other D. Antiviral E. Antifungal 16. What type of drug is Amphotericin B? A. Antibacterial, targets cell wall synthesis B. Antibacterial, targets ribosomes/protein synthesis C. Antibacterial, other
Label the image to review major targets of drugs acting on bacterial cells. Cephalosporins Protein synthesis inhibitors acting on ribosomes Cell membrane Sulfonamides (sulfa drugs) Cell wall inhibitors Penicillins Polymyxins Erythromycin Aminoglycosides Quinolones Folic acid synthesis DNA/RNA Rifampin
Antibiotic A: 0.5 kDa protein, targets peptidoglycan Antibiotic B: 20 kDa protein, targets peptidoglycan Antibiotic C: Cationic Antimicrobial Peptide (CAMP) Antibiotic D: Targets lipopolysaccharide With some more searching, you found the following results in your notebook. Percent Survival Percent Survival Antibiotic Antibiotic Control Control protoplast C. difficile protoplast Bacteria S. aureus E. coli V. cholera C. difficile S. aureus E. coli V. cholera Bacteria Percent Survival Percent Survival Antibiotic Antibiotic Control Control E.coli S. aureus Bacteria S. aureus E. colis...
When the Rb protein is phosphorylated it allows the cell to progress through the__checkpoint. OG1 OM os OG2 Question 8 2 pts What is the function of cyclin-CDK complexes? They prevent DNA replication from occurring so that a cell cannot go through the cell cycle The function as growth factors which tell the cell to divide when necessary They prevent a cell from being able to enter meiosis They phosphorylate cellular targets which allows the cell to progress to the...
Drag the appropriate labels to their respective targets. Reset Help Cell body Satellite cell Peripheral axon Central axon Schwann cell NEUROGLIAL CELL TYPE FUNCTION • Myelinate certain axons in the PNS • Surround and support cell bodies
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycle. Why doesn't this Cdk activate G1-, S-, G2-, and M-phase proteins all at the same time? B. Please describe how cell death by apoptosis can play a beneficial role in the body's healthy growth. C. For a cell starting in G1, place the following cell cycle events in...
4. Short response (2 sentences max, 6pts each) A. Many yeast species have only one cyclin-dependent kinase (Cdk), which activates protein targets that drive events in multiple phases of the cell cycle. Why doesn't this Cdk activate G1-, S-, G2-, and M-phase proteins all at the same time? B. Please describe how cell death by apoptosis can play a beneficial role in the body's healthy growth. C. For a cell starting in G1, place the following cell cycle events in...
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