Question

immunology:

1. Indicate what step is correct (Select all that apply)

1. Lymphocytes travel through the body in the lymph as well as the blood
2. Lymphocytes leave the blood through the walls of fine capillaries in 2ry lymphoid organs
3. After spending some time in the LN, lymphocytes leave in the efferent lymph
4. Lymphocytes return to blood at the subclavian vein
5. A lymphocyte after encounter an antigen to which its receptor binds, stops recirculating.
6. The spleen has no connection to the lymphatic system
7. Lymphocytes enter and leave the spleen through blood vessels

2. All of the following occur after B cells leave the bone marrow except

1. Peripheral Tolerance
2. Receptor editing
3. Differentiation into plasma cells
4. Production of memory B cells
5. Recirculation between lymph, blood, and 2ry lymphoid tissues

3. Developing B cells that fail to make productive D to J heavy-chain rearrangements on both homologous chromosomes

1. Die by apoptosis in the bone marrow
2. Will rearrange heavy-chain loci multiple times until a productive rearrangement is made
3. Undergo clonal proliferation
4. Fail to rearrange V to DJ

Answer 1

1. A and f

2. B receptor editing

- after leaving the bone marrow, B cell mediate through peripheral tolerance, differentiation in plasma cell, induction of memory cells, circulation between tissues.

3. A (die by apoptosis in the bone marrow.)