Which of the following is not a Phase I reaction?
a. Oxidation b. Hydrolysis c. Epoxidation d. N-dealkylation
e. Acetylation
The answer is e) Acetylation
Because acetylation, sulfation, glucuronidation are Phase II reaction metabolites and hydrophilic in nature.
Whereas, oxidation, reduction, Hydrolysis, Epoxidation are Phase I reaction metabolites and are Lipophilic in nature.
Which of the following is not a Phase I reaction? a. Oxidation b. Hydrolysis &nb
10) Which of the following is always true for the oxidation numbers in an oxidation-reduction reaction? a) The value for the oxidation number for atoms of the element being oxidized must increase as we go from reactants to products b) The initial value for the oxidation number for atoms of the element being oxidized must be positive c) The final value for the oxidation number for atoms of the element being oxidized must be positive d) Both band c e)...
Which of the following reaction is a syn addition(s)? A. Hydroboration-oxidation of alkenes B. Hydrohalogenation reaction of alkenes C. Dihalogenation reaction alkenes D. Halohydrin formation reaction 7. Consider the three compounds below: 1. CH CH OCH CH, II. CH CH CH CH CH, M.CH, CH2CH2CH2OH The two most similar in boiling point are: A. I and II B . I and III C. II and III D. There is no way to judge since no boiling point is provided for...
10) Which of the following is always true for the oxidation numbers in an oxidation-reduction reaction? a) The value for the oxidation number for atoms of the element being oxidized must increase as we go from reactants to products b) The initial value for the oxidation number for atoms of the element being oxidized must be positive c) The final value for the oxidation number for atoms of the element being oxidized must be positive d) Both b and c...
10) Which of the following is always true for the oxidation numbers in an oxidation-reduction reaction? a) The value for the oxidation number for atoms of the element being oxidized must increase as we go from reactants to products b) The initial value for the oxidation number for atoms of the element being oxidized must be positive c) The final value for the oxidation number for atoms of the element being oxidized must be positive d) Both b and c...
Which of the following metabolic reactions are possible for procainamide, shown below? O-dealkylation Hydrolysis Acetylation N-dealkylation ZI H2N
5. Which of the following would be the least likely to occur during glycolysis? a) Hydrolysis of ATP b) Synthesis of ATP c) Reduction of NAD+ d) Oxidation of NADH e) There are two that are equally likely
#310 of Functional Group Chemistry Which of the following would undergo a hydrolysis reaction? Lº W Y dimethylether dimethylamine methyl acetate N,N-dimethylacetamide Select one: o a. dimethylamine and dimethylether O b. dimethylether only c. methyl acetate only O d. methyl acetate and N,N-dimethylacetamide o e. dimethylamine only
1. Which of the following has the fastest rate of hydrolysis to acetic acid i ii ia H,C-CEN INHER 2. What is the product of the following reaction? cat. NaOH HH VH A. 2-hydroxy-2-methylpropanal B. 3-hydroxy-2-methylbutanal C. 3-hydroxy-2-methylpentanal D. 3-hydroxy-2-methylpropanal E. 2-hydroxy-3-methylhexanal 3. What is the product of the following reactions OH NaBH4 MeOH/H,0 O NISHA SOH COM i none of A-D
25. Recognizing Reaction Types For the following pairs of biomolecules, identify the type of reaction (oxidation- reduction, hydrolysis, isomerization, group transfer, or internal rearrangement) required to convert the first molecule to the second A) Acetyl-CoA Acetate + COA-S B) Citrate socitrate CH2-OPO C) Glucose Fructose Glucose Glucose 6-phosphate Çooº E) Glycerol (Glycerin) çoo- - HO-C-H. *# H-C- он он он * - CH2 I TYCH opo Coo- coo L-Malate Glycerol-3-phosphate Oxaloacetate
1. Explain or describe Albumin Binding. 2. Explain how oxidation influence Glutathione conjugates, Sulfation, Methylation, and Glucuronidation. 3. List Toxic Xenobiotics Classed by Reactive Metabolites/Intermediates. 4. Explain or describe Phase I Oxidations. 5. Describe a notable feature of flavin monoxygenases. 6. Cytochrome P450 family members can differ in various aspects. The developed nomenclature is based on amino acid homology. List four sources for this nomenclature: 7. Explain or describe Phase I Hydrolysis. 8. Explain or describe glucuronidation. 9. Explain or...