Question

Receptors are capable of binding different chemical molecules, having impact on potential downstream signalling. Within this context,

differentiate between endogenous hormones, agonists, and antagonists for a NUCLEAR RECEPTOR.

Answer 1

Answer :)

Endogenous hormones are derived from biological organs. Therefore, these are controllable in vivo. Hormones may activate or deactivate any process. Feedback regulation controls the hormonal secretion. Therefore, their binding on the receptor is temporarily and affects by other products or hormones.

Agonists are activators of a process and bind to the same receptor as the hormone. Agonists are not controllable by feedback inhibition because these are external chemicals. Agonists can be either permanent or temporary.

Antagonists have the opposite function of agonists. Antagonists restrict the function of agonists. Antagonists are also either permanent or temporary.