2. a) Sketch a eukaryotic gene (brns) that is regulated by one transcription factor - Brt...
2.
a) Sketch a eukaryotic gene (brns) that is regulated by one transcription factor - Brt - that bind 50 bps upstream of the transcription start site and an enhancer - Ned - that binds 10 kb upstream of the transcription start site. In your sketch, indicate the
- start of transcription,
- TATA box
- beginning of the open reading frame for your gene (ATG),
- location of the promoter,
- location of the transcription factors,
- location of the RNA polymerase II,
- location of the transcription factor and the enhancer.
Draw all proteins as ovals and the start of transcription as a right-angled arrow.
b) A mutation in the Brt transcription factor causes a dramatic reduction in brns transcription. Describe (or sketch) a possible reason for this reduction in transcription.
Homework Answers
Add Answer to:
2.
a) Sketch a eukaryotic gene
(brns) that is regulated by one transcription factor - Brt...
Which of the following correctly describes eukaryotic transcriptional control? a. A transcription factor is a...
Which of the following correctly describes eukaryotic transcriptional control? a. A transcription factor is a DNA molecule that helps RNA polymerase to bind to the enhancer of a specific gene. b. An enhancer is a protein that encourages gene expression by binding to the DNA. c. The promoter is the region of RNA where DNA polymerase will bind to begin transcription. d. The interaction of multiple transcription factors may be required in order to transcribe a...
Question 1 Match the term with the best definition or description; most topics relate to the...
Question 1 Match the term with the best definition or description; most topics relate to the regulation of gene expression. General type of protein which will increase transcription rates when it attaches to a site A. Factor connected to a particular gene - B. Co-repressor C. Enhancer D. Promoter E. Structural F. Intron G. Activator H. Operator I. Basal transcription J. Glucocorticoid receptor K. Sigma factor L. Mediator M. Inducer N. TATA box O. Repressor The rates of mRNA produced...
3. Prokaryotic and eukaryotic gene expression compared. Below is an incomplete table of prokaryotic and eukaryotic...
3. Prokaryotic and eukaryotic gene expression compared. Below is an incomplete table of prokaryotic and eukaryotic gene expression in comparison. Fill in the blank using PPT slides, notes and the textbook. Prokaryotic gene expression Eukaryotic gene expression Overview Steps Transcription and translation Yes Transcription and translation coupled? Gene structure No introns Epigenetic modification (chromosome remodeling) transcription, translation, RNA processing, protein processing Transcription in the nucleus and translation in the cytoplasm Interrupted gene with exons and introns RNAPI, II, III Which...
Question 20 TFIID is a. a protein and a transcription factor. b. an enzyme. c. a...
Question 20 TFIID is a. a protein and a transcription factor. b. an enzyme. c. a promoter and a transcription factor. d. a promoter. e. part of the TATA box. Question 19 Without maintenance methyltransferase, the changes made by DNA methyltransferase would not a. be able to increase transcription of a gene. b. be passed on from one generation to the next c. coordinate regulation across different genes. d. produce microRNA. e. be able to decrease transcription of a gene....
The following is a diagram of the LCT (lactase gene) gene regulation system in humans. When...
The following is a diagram of the LCT (lactase gene) gene
regulation system in humans. When the LCT gene is transcriptionally
active, the cell produces the enzyme lactase, which is
needed to digest the lactose in many dairy products. Based on what
you know about enhancers and promoters from your reading, predict
how the following scenarios might influence LCT gene expression and
thus lactase production in cells:
The enhancer sequence is inverted, but remains intact so that
Oct1 still binds...
Draw a Eukaryotic Gene Schematic Draw features of importance at the DNA level Transcription start site...
Draw a Eukaryotic Gene Schematic Draw features of importance at the DNA level Transcription start site +1 Promoter - as much detail as you can Gene start ATG and stop codons Transcription Regulatory Sequences such as activators/repressors and enhancers/insulators Draw features of importance at the pre-mRNA level Designate Introns and Exons Designate important Sequences to direct and regulate splicing three important sequences for the chemistry of splicing splicing regulatory sequences (ISS, ISE, ESE, ESS) Modifications at level of pre-mRNA UTRs,...
Please explain your answers as best as you can. I want to be able to understand....
Please explain your answers as best as you can. I want to be
able to understand.
The first drawing below represents the transcription start site and upstream region of a eukaryotic gene. In addition, four deletion constructs are shown, where the unboxed area represents a deletion of upstream DNA. Note the location of the +1 start site and the promoter, which includes the TATA box Non-deleted DNA template and DNA of the various deletions constructs were added to both systems...
Genetics Worksheet Week 3: Gene Regulation and Epigenetics 1. Duchenne muscular dystrophy is caused by a mutation in a gene that is 2.5 million nucleotides in length and encodes a protein called dyst...
Genetics Worksheet Week 3: Gene Regulation and Epigenetics 1. Duchenne muscular dystrophy is caused by a mutation in a gene that is 2.5 million nucleotides in length and encodes a protein called dystrophin. The dystrophin protein itself is 3684 amino acids in length. Calculate below the approximate size of the mRNA that encodes dystrophin. Approximately what percentage of the gene that encodes dystrophin is intron sequence? The human genome encodes a much greater variety and number of proteins than the...
can someone explain how to answer this with reasons why 30-45 mins after estrogen addition: Acchyiase...
can someone explain how to answer this with reasons why
30-45 mins after estrogen addition: Acchyiase (HAT, odde auhye 60-90 mins after estrogen addition: Reauitment ef Poy to open 7. T identify the Gene X DNA element responsible for regulation by a Growth Fagor, you perform a linker scanning experiment in which you mutate 10 bp Tegions centered around positions -205 to-5 in the Gene X promoter/promoter- proximal region (wt wild-type promoter). The promoter variants were tested for their ability...
For the next group of questions consider a diploid cell from a eukaryotic organism with a...
For the next group of questions consider a diploid cell from a eukaryotic organism with a total of ten chromosomes. After one round of the cell cycle is complete you observe a total of four daughter cells. During this cell division occurred and the resulting daughter cells are. mitosis; haploid with ten total chromosomes each mitosis; diploid with five total chromosomes each meiosis; diploid with ten total chromosomes each meiosis; haploid with five total chromosomes each Before the cell divided,...
Question 1 Match the term with the best definition or description; most topics relate to the regulation of gene expression. General type of protein which will increase transcription rates when it attaches to a site A. Factor connected to a particular gene - B. Co-repressor C. Enhancer D. Promoter E. Structural F. Intron G. Activator H. Operator I. Basal transcription J. Glucocorticoid receptor K. Sigma factor L. Mediator M. Inducer N. TATA box O. Repressor The rates of mRNA produced...
3. Prokaryotic and eukaryotic gene expression compared. Below is an incomplete table of prokaryotic and eukaryotic gene expression in comparison. Fill in the blank using PPT slides, notes and the textbook. Prokaryotic gene expression Eukaryotic gene expression Overview Steps Transcription and translation Yes Transcription and translation coupled? Gene structure No introns Epigenetic modification (chromosome remodeling) transcription, translation, RNA processing, protein processing Transcription in the nucleus and translation in the cytoplasm Interrupted gene with exons and introns RNAPI, II, III Which...
Question 20 TFIID is a. a protein and a transcription factor. b. an enzyme. c. a promoter and a transcription factor. d. a promoter. e. part of the TATA box. Question 19 Without maintenance methyltransferase, the changes made by DNA methyltransferase would not a. be able to increase transcription of a gene. b. be passed on from one generation to the next c. coordinate regulation across different genes. d. produce microRNA. e. be able to decrease transcription of a gene....
The following is a diagram of the LCT (lactase gene) gene
regulation system in humans. When the LCT gene is transcriptionally
active, the cell produces the enzyme lactase, which is
needed to digest the lactose in many dairy products. Based on what
you know about enhancers and promoters from your reading, predict
how the following scenarios might influence LCT gene expression and
thus lactase production in cells:
The enhancer sequence is inverted, but remains intact so that
Oct1 still binds...
Draw a Eukaryotic Gene Schematic Draw features of importance at the DNA level Transcription start site +1 Promoter - as much detail as you can Gene start ATG and stop codons Transcription Regulatory Sequences such as activators/repressors and enhancers/insulators Draw features of importance at the pre-mRNA level Designate Introns and Exons Designate important Sequences to direct and regulate splicing three important sequences for the chemistry of splicing splicing regulatory sequences (ISS, ISE, ESE, ESS) Modifications at level of pre-mRNA UTRs,...
Please explain your answers as best as you can. I want to be
able to understand.
The first drawing below represents the transcription start site and upstream region of a eukaryotic gene. In addition, four deletion constructs are shown, where the unboxed area represents a deletion of upstream DNA. Note the location of the +1 start site and the promoter, which includes the TATA box Non-deleted DNA template and DNA of the various deletions constructs were added to both systems...
Genetics Worksheet Week 3: Gene Regulation and Epigenetics 1. Duchenne muscular dystrophy is caused by a mutation in a gene that is 2.5 million nucleotides in length and encodes a protein called dystrophin. The dystrophin protein itself is 3684 amino acids in length. Calculate below the approximate size of the mRNA that encodes dystrophin. Approximately what percentage of the gene that encodes dystrophin is intron sequence? The human genome encodes a much greater variety and number of proteins than the...
can someone explain how to answer this with reasons why
30-45 mins after estrogen addition: Acchyiase (HAT, odde auhye 60-90 mins after estrogen addition: Reauitment ef Poy to open 7. T identify the Gene X DNA element responsible for regulation by a Growth Fagor, you perform a linker scanning experiment in which you mutate 10 bp Tegions centered around positions -205 to-5 in the Gene X promoter/promoter- proximal region (wt wild-type promoter). The promoter variants were tested for their ability...
For the next group of questions consider a diploid cell from a eukaryotic organism with a total of ten chromosomes. After one round of the cell cycle is complete you observe a total of four daughter cells. During this cell division occurred and the resulting daughter cells are. mitosis; haploid with ten total chromosomes each mitosis; diploid with five total chromosomes each meiosis; diploid with ten total chromosomes each meiosis; haploid with five total chromosomes each Before the cell divided,...
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