Question

1) Which of the following is true about binding sites in proteins?

A. Binding sites often resemble cavities in the surface of the protein.

B. Binding sites form on the surface of the protein when a ligand is present.

C. Binding sites typically rely on covalent forces for tight binding.

D. Amino acids making up the binding site must be located close together in the primary sequence.

Answer 1

Answer: Option A is correct
Explanation:
Binding sites represent the locations on the protein surface where a ligand binds. They represent small cavities on the protein surface formed by the tertiary structure of the protein.
Binding sites are present on the protein irrespective of the presence or absence of the ligand. However, the binding site may alter its topology during ligand binding.
Binding sites rely on non-covalent interactions such as hydrogen bonds and hydrophobic interactions.
Binding sites are formed by the tertiary structure of the protein.