3. Explain how activation of diacylglycerol (DAG) kinase (converts DAG to phosphatidic acid) would affect signaling in the phosphoinositide pathway
3ANS)
--> Diacylglycerol with the assistance of calcium particles is in charge of initiation of protein kinase C in the phosphoinositide pathway. At the point when diacylglycerol kinase gets enacted, it will change over diacylglycerol to phosphatidic corrosive. Consequently, there will no diacylglycerol to actuate protein kinase C. This is the reason the initiation of diacylglycerol kinase would restrain motioning by the phosphoinositide pathway.
3. Explain how activation of diacylglycerol (DAG) kinase (converts DAG to phosphatidic acid) would affect signaling...
A. B. C. D. E. F. Thank you receptors induce activation of adenlyate cyclase, which creates the second messenger(s) O G-Protein Coupled, CAMP O Tyrosine Kinase, CAMP OTyrosine Kinase, IP3 and DAG G-Protein Coupled, IP3 and DAG Which of the following is most likely to be activated by a small hydrophobic signal? OIntracellular receptor Receptor Tyrosine Kinase O G-Protein Coupled Receptor Ligand-Gated lon Channel Which of the following types of receptors require dimerization for activation? (Select any/all that apply) OLigand-gated...
Activity 4. Receptor signaling pathway A model of a G protein receptor signaling pathway is represented below. Activation of the signaling pathway results in a cell secreting a neurotransmitter through exocytosis. Activated - Activated adenylyl receptor cyclase GTP АТР CAMP Active G protein Protein- kinase A Inactive Active Protein targets Phosphate group A. Different steps in a signaling pathway can amplify the initial signal of one ligand binding to one receptor. Choose one step in the pathway below that results...
Describe how a single protein in the tyrosine kinase signaling pathway possesses all the protein functions that characterize signal transduction.
Name at least two potential proteins within this pathway that could be Mutant A. Explain why. wt cells Mutant A Mutant B Mitogen 120 KDa | 110 KDa 100 KDa- 65KDa Figure 1: Newly identified MAP kinase signaling pathway mutants exhibit opposite effects. WT, Mutant A, and Mutant B cells were (+), and were not (), exposed to a signaling pathway stimulatory mitogen. Random mutations introduced to CHO cells then downstream S-cyclin expression was monitored to indicated MAP kinase signaling...
-Describe how trimeric G proteins get activated and inactivated - Name the two common second messengers In what signaling pathways do these messengers get activated (Yes, you do need to know the names of the key players in the pathway!)? What can the second messenger then do? What two criteria are needed for activation of a receptor tyrosine kinase? -Describe how monomeric Ras is activated and what does Ras do upon activation. (Again, you must know the signaling pathway) -Describe...
1. How does a PTB domain differ from and SH2 domain? 2. Which signaling pathway evokes most of the transformation phenotypes induced by the Ras oncoprotein? 3. Briefly explain how the AKT kinase gets recruited to the plasma membrane in response to PI3K signaling 4. How does the PTEN phosphatase negatively regulated AKT kinase?
An increase in intracellular phosphoinositol 3,4,5 triphosphosphate (PIP3): leads to the activation of PI-3 kinase. leads to glucose absorption via GLUT 4 in the muscle and adipose. is accomplished by the GTP-bound Gs alpha-subunit. leads to glycogen breakdown in the liver. is an intermediate in glucagon signaling that primarily occurs in the liver and adipose tissues. The following metabolic effects are accomplished by glucagon signaling: mobilization and fusion with the membrane of GLUT 4 carrying vesicles within adipose and muscle...
Hormonal activation of insulin levels will: o activate protein kinase A phosphorylation of FBPase2. O phosphorylate PFK2 on a tyrosine residue. O lead to the activation of PFK. O activate the PKC phosphorylation of PFK2. O increase the activation of glucolysis. How many electrons does one turn of the TCA cycle produce? O 3 06 08 O 10 O None of answers are correct Which of the following statements is correct about oxidative pentose phosphate pathway? o It generates NADH...
A complex signaling pathway in yeast allows the cells to accumulate high concentrations of glycerol if they are exposed to high extracellular concentration of salt or glucose. The increased osmolarity of the extracellular medium activates Ras, which in turn activates adenylate cyclase. A second pathway, the HOG (high osmolarity glycerol) pathway activates the MAP kinase pathway. The target protein is the enzyme PFK2, which is activated by phosphorylation. (PFK2 produces an allosteric regulator that activates glycolysis, which ultimately produces glycerol.)...
Drosopholia eye development is an example of cell differentiation directed by signal binding to a receptor tyrosine kinase (RTK). In this pathway, R7 photoreceptor development requires a receptor (SEV, sevenless), which is activated by binding to a plasma membrane bound signal (BOSS, bride-of-sevenless) displayed on the adjacent R8 cell Receptor activation leads to activation of RAS via two proteins, Drk (down- stream of receptor kinases) and Sos (son-of-sevenless). Activated RAS leads to activation of a phosphorylation cascade that activates the...