-Describe how trimeric G proteins get activated and inactivated - Name the two common second messengers In what signaling pathways do these messengers get activated (Yes, you do need to know the...
1. Explain the signaling cascade downstream of GPCR: • How trimeric G-protein is activated and inactivated? • What do a and By subunits do after G-protein activation?
Classes 7-8 Cytoplasmic Growth Signaling Be able to describe Ras structure and function. What kind of protein is it? How is it regulated (Fig. 5.30)? How many forms of Ras do humans express? Be able to describe how Ras interacts with multiple downstream partners. What mechanisms render ras oncogenic? Also, how does Ras become oncogenic in the absence of ras mutations? Be able to describe how Ras interacts with the growth factor receptor signaling machinery. How did fly genetics help...
The small monomeric G protein Ras is an important component of most receptor tyrosine kinase signaling pathways. It can regulate a number of downstream signaling components, perhaps most famously the MAPK cascade. Unlike other monomeric G proteins that we have discussed previously in class, Ras is anchored at the plasma membrane by a covalently bound lipid anchor. If Ras was specifically mutated so that it did not get this lipid modification (but was otherwise completely unchanged), what do you hypothesize...
1. According to the paper, what does lactate dehydrogenase (LDH) do and what does it allow to happen within the myofiber? (5 points) 2. According to the paper, what is the major disadvantage of relying on glycolysis during high-intensity exercise? (5 points) 3. Using Figure 1 in the paper, briefly describe the different sources of ATP production at 50% versus 90% AND explain whether you believe this depiction of ATP production applies to a Type IIX myofiber in a human....