Cystic fibrosis (CF) is caused by recessive loss-of-function mutations for a cell surface protein expressed in...

Question

Question

Cystic fibrosis (CF) is caused by recessive loss-of-function mutations for a cell surface protein expressed in...

Cystic fibrosis (CF) is caused by recessive loss-of-function mutations for a cell surface protein expressed in the mucus membranes of intestines and lungs. Until recently, few affected individuals survived to reproductive age. In Caucasian populations, CF affects 1 infant in 2,500 births. What is the frequency of CF homozygotes?
Based on the genotype frequency, what is the frequency of the CF allele?
Given a selection coefficient of 1, what would be the mutation rate needed to keep CF in the population at its current allele frequency?
The estimated mutation rate of CF is 6.7 x 10-7. What does this suggest about the likelihood of CF being maintained by mutation-selection balance?

science biology

Add a comment Improve this question Transcribed image text

Answer 1

Answer #1

Add a comment

Answer 2

Similar Homework Help Questions

(3 parts for the answers) Cystic Fibrosis Cystic fibrosis is an autosomal recessive disorder that affects...

(3 parts for the answers) Cystic Fibrosis Cystic fibrosis is an autosomal recessive disorder that affects 1 in 3 000 newborns with a Caucasian background. It causes thick mucus build up in various organs and can cause damages and problems in respiratory and digestive systems. --What is the frequency of the cystic fibrosis allele in the Caucasian population? Show all your work and express your answer as a value between 0 and 1 rounded to two decimal places --What percentage...
Cystic fibrosis is an autosomal recessive disease caused by a mutation in a single gene with...

Cystic fibrosis is an autosomal recessive disease caused by a mutation in a single gene with two alleles. Suppose the frequency of cystic fibrosis in a population is 3%. Assuming the gene is in HW equilibrium, calculate the allele and genotype frequencies. If the population consists of 100 individuals, how many are carriers (but unaffected) for the cystic fibrosis allele?
I really want to understand this, please help step by step Cystic fibrosis is a Mendelian...

I really want to understand this, please help step by step Cystic fibrosis is a Mendelian recessive disease of humans caused by defects in ion transport (OMIM 602421). Until the 1950's when antibiotics were first used to treat CF patients, most newborns with CF died at an early age. Yet CF is relatively common in Caucasians, with a frequency of an allele that is lethal to homozygotes. There is no agreement on the reason for this high frequency. a) Suppose...

3. Cystic fibrosis (CF) is an autosomal recessive disorder (cc) and is one of the most...

3. Cystic fibrosis (CF) is an autosomal recessive disorder (cc) and is one of the most common life-shortening genetic diseases. In the United States, 1 in 4,000 children are born with CF. Symptoms of cystic fibrous include the production of salty sweat and thickened mucus in the lining of the lungs and air passages. The thickened mucus obstructs airways and promotes the growth of disease-causing bacteria in the lungs. Most individuals with cystic fibrous die in their 20s and 30s...
82 GENETICS LABORATORY MANUAL 4. Cystic fibrosis is one of the most common autosomal recessive diseases...

82 GENETICS LABORATORY MANUAL 4. Cystic fibrosis is one of the most common autosomal recessive diseases in people Northern European descent. A mutation in the CF gene affects a protein involved in the transport of chloride and sodium across cell membranes, causing thick mucus and secretions, lung damage, and nutritional deficiencies. The disease is inherited in an autosomal recessive manner, meaning one must inherit two mutated alleles in order to have the disease. Greg does not have cystic fibrosis, and...
Cystic fibrosis (CF) is an inherited disorder caused by different types of mutations, many of which...

Cystic fibrosis (CF) is an inherited disorder caused by different types of mutations, many of which prevent ions from moving across cell membranes. Normally there are channel proteins that allow passage of the ions, but in patients with one kind of CF these proteins seem odd. Closer examination shows that these proteins display the correct amino acid sequence. However, they fail to do their job. A) Given that the primary structure of the protein is correct, what can you infer...

Cystic fibrosis (CF) is an inherited disorder caused by different types of mutations, many of which...

Cystic fibrosis (CF) is an inherited disorder caused by different types of mutations, many of which prevent ions from moving across cell membranes. Normally there are channel proteins that allow passage of the ions, but in patients with one kind of CF these proteins seem odd. Closer examination shows that these proteins display the correct amino acid sequence. However, they fail to do their job. A) Given that the primary structure of the protein is correct, what can you infer...
PEDIGREE ANALYSIS Cystic fibrosis is a recessive inherited disorder that affects one in 2,500 people of...

PEDIGREE ANALYSIS Cystic fibrosis is a recessive inherited disorder that affects one in 2,500 people of European descent. People afflicted with this condition have defective or absent protein channels which causes an accumulation of extracellular chloride ions, leading to a buildup of mucus around the lungs and digestive system. This sticky mucus clogs the lungs leading to life-threatening lung infections, and also obstructs the pancreas and causes poor absorption of food. With treatment, individuals can live into their 30's and...
4) Cystic fibrosis is a human disease caused by an autosomal recessive mutation. About 1 in...

4) Cystic fibrosis is a human disease caused by an autosomal recessive mutation. About 1 in 22 people in the human population are heterozygous carriers and have no symptoms of the disease. A woman who has a brother with CF marries a man who has no history of CF in his family a) What are the possible genotypes of the woman? b) What is the most likely genotype of the man? c) What is the percentage of offspring that would...

Tony has a sister with cystic fibrosis (CF). Neither of his parents have CF. Tony is...

Tony has a sister with cystic fibrosis (CF). Neither of his parents have CF. Tony is expecting a child with Tina. Tina's family history is unknown. (8 points) Below each person in the pedigree, write his or her genotype, or possible genotypes, using C for the normal CF allele and c for the disease-causing CF recessive allele. What is the probability that Tony is a heterozygous carrier for the CF gene? Explain your answer. п CF Tony Tina III If...

Cystic fibrosis (CF) is caused by recessive loss-of-function mutations for a cell surface protein expressed in...

Homework Answers

Add Answer to:
Cystic fibrosis (CF) is caused by recessive loss-of-function mutations for a cell surface protein expressed in...

Post as a guest

Earn Coins

(3 parts for the answers) Cystic Fibrosis Cystic fibrosis is an autosomal recessive disorder that affects...

Cystic fibrosis is an autosomal recessive disease caused by a mutation in a single gene with...

I really want to understand this, please help step by step Cystic fibrosis is a Mendelian...

3. Cystic fibrosis (CF) is an autosomal recessive disorder (cc) and is one of the most...

82 GENETICS LABORATORY MANUAL 4. Cystic fibrosis is one of the most common autosomal recessive diseases...

Cystic fibrosis (CF) is an inherited disorder caused by different types of mutations, many of which...

Cystic fibrosis (CF) is an inherited disorder caused by different types of mutations, many of which...

PEDIGREE ANALYSIS Cystic fibrosis is a recessive inherited disorder that affects one in 2,500 people of...

4) Cystic fibrosis is a human disease caused by an autosomal recessive mutation. About 1 in...

Tony has a sister with cystic fibrosis (CF). Neither of his parents have CF. Tony is...

Cystic fibrosis (CF) is caused by recessive loss-of-function mutations for a cell surface protein expressed in...

Homework Answers

Add Answer to: Cystic fibrosis (CF) is caused by recessive loss-of-function mutations for a cell surface protein expressed in...

Post as a guest

Earn Coins

Add Answer to:
Cystic fibrosis (CF) is caused by recessive loss-of-function mutations for a cell surface protein expressed in...