Questions about Cellular Neurobiology 7. How are microtubules post-translationally modified? What is the significance of these...
Questions about Cellular Neurobiology
7. How are microtubules post-translationally modified? What is the significance of these modifications?
Homework Answers
Ans.) Microtubules are have multiple roles inside a cell like cell motility, inner cellular trafficking, cell growth, etc. Post translation modification of these cytoskeletal proteins modifies its functions. It is a process of addition of certain chemical groups to amino acid chain. Post transnational modification of tubulin includes tyronisation/detyronisation, ubiquitinization, acetylation, phophorylation, glutamylation, glycylation, etc.
PTMs modifies its function in various ways like tyronisation/detyronisation increases stability of microtubule and it's interaction with microtubule associated proteins. Acylated microtubule are found in many structures like flagella of algae, neurons, cillia, spindle MT, but actual function is unknown.
Other modificational functions are little unclear. However, are required for activation and inactivation of microtubules.
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